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Pregled bibliografske jedinice broj: 50521

Časopis

Autori: Nagy, Biserka; Yeh, Wen-Chen; Mak, Tak W.; Chiu, Song-Mao; Šeparović, Duška
Naslov: FADD Null Mouse Embryonic Fibroblasts Undergo Apoptosis after Photosensitization with the Silicon Phthalocyanine Pc 4
( FADD Null Mouse Embryonic Fibroblasts Undergo Apoptosis after Photosensitization with the Silicon Phthalocyanine Pc 4 )
Izvornik: Archives of Biochemistry and Biophysics (0003-9861) 385 (2001), 1; 194-202
Vrsta rada: članak
Ključne riječi: apoptosis; ceramide; FADD; PDT; Pc 4; TNH-alpfa
( apoptosis; ceramide; FADD; PDT; Pc 4; TNH-alpfa )
Sažetak:
Oxidative stress, such as photodynamic therapy with the silicon phthalocyanine Pc 4 (Pc 4-PDT), can induce apoptosis and tumor necrosis factor alpha (TNF) production. TNF receptors, as well as other death receptor, have been implicated in stress-induced apoptosis. To assess directly the role of FADD, a death receptor-associated protein, in induction of apoptosis post-Pc 4-PDT, embryonic fibroblasts from FADD knock out (k/o) and wild-type (wt) mice were used. Pc 4-PDT induced casp-3 activation and apoptosis in both cell types. In the presence of zVAD, a pan-caspase inhibitor, Pc 4-PDT-induced apoptosis was abrogated in both cell lines. Fumonisin B1 (FB), an inhibitor of ceramide synthase, had no effect on apoptosis after Pc 4-PDT in eitherl cell line. Simiral to Pc 4-PDT, exogenous C6-ceramide bypassed FADD deficiency and induced zVAD-sensitive and FB-insensitive. Induced ceramide levels remained elevated after cotreatment with TNF and zVAD in FADD wt cells. Taken together, these data provide genetic evidence for a lack of FADD requirement in Pc 4-PDT- or C6-ceramide-induced apoptosis. FB-sensitive ceramide production accompanies, but does not suffice, for apoptosis after Pc 4 photosensitization of TNF.
Projekt / tema: 119118
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Biologija
URL cjelovitog teksta:
Google Scholar: FADD Null Mouse Embryonic Fibroblasts Undergo Apoptosis after Photosensitization with the Silicon Phthalocyanine Pc 4



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