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Pregled bibliografske jedinice broj: 50557

Časopis

Autori: Popović Hadžija, Marijana; Kapitanović, Sanja; Radošević, Senka; Čačev, Tamara; Mirt, Mirela; Kovačević, Duje; Lukač, Josip; Hadžija, Mirko; Spaventi, Radan; Pavelić, Krešimir
Naslov: Loss of heterozygosity of DPC4 tumor suppressor gene in human sporadic colon cancer
Izvornik: Journal of Molecular Medicine (0946-2716) 79 (2001), 2-3; 128-132
Vrsta rada: članak
Ključne riječi: Colon cancer; Tumor suppressor gene; DPC4; Loss of hetrozygosity
Sažetak:
We investigated the prevalence of DPC4 loss of heterozygosity in sporadic colorectal cancer. Thirty-six cases of human spordic colon carcinoma and corresponding normal tissue samples were examined to evaluate loss of heterozygosity at the DPC4 tumor suppressor locus using variable nucleotide tandem repeat (VNTR) analysis and three polymorfic markers. From 36 analyzed samples 35 (97%) were heterozygous or informative. Loss of heterozygosity at the DPC4 locus was detected in 18(51%) of informative tumor DNAs. The DPC4 LOH was more frequent in smaller tumors(<5 cm) than in larger ones. Thre was no correlation between DPC4 LOH and age or sex of patients. There was a negative correlation between DPC4 LOH and histological grade or DUKES' stage of tumors, but without statistic significance, Observed results were in agreement with the view that malignant progression is concequence of many genetic changes. it can be concluded that inactivation of the DPC4 gene plays a role in a multistep process of outhrowth and progression of colon cancer.
Projekt / tema: 00981104, 00981109, 101751, 134002
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL cjelovitog teksta:
Google Scholar: Loss of heterozygosity of DPC4 tumor suppressor gene in human sporadic colon cancer



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