crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 506522

Zbornik radova

Autori: Čaplar, Vesna; Frkanec, Leo; Žinić Mladen
Naslov: Bio-inspirirani gelatori. Sinteza i samo-udruživanje peptidnih gelatora s KLVFF fragmentom amiloidnog Aβ-proteina
( Bio-inspired gelators. Synthesis and self-assembly of peptidic gelators containing KLVFF sequence of the amyloid Aβ- protein. )
Izvornik: Book of Abstracts / Tomašić, Vesna ; Maduna Valkaj, Karolina (ur.). - Zagreb :
Skup: XXII. Hrvatski skup kemičara i kemijskih inženjera
Mjesto i datum: Zagreb, 13-16.02.2011.
Ključne riječi: Bio-inspirirani gelatori; samo-udruživanje; amiloidni Aβ-protein
( Bio-inspired gelators; self-assembly; amyloid Aβ- protein )
Sažetak:
The amyloid fibrils self-assembled from Aβ-protein are considered the most responsible for the formation of senile plaques of Alzheimer's disease. The KLVFF sequence of Aβ-protein seems to be the most important for its self-assembly into fibrous amyloidal aggregates and some short peptides containing the same sequence were also shown to bind to the amyloids. [1, 2]. A series of KLVFF containing peptidomimetics substituted at N and C termini with alkyl chains of various lengths were synthesized and tested for gelation of water and DMSO/water mixtures. The results of spectroscopic (1H-NMR, FTIR), morphology (TEM) and X-ray diffraction studies of formed gels revealed formation of fibrous aggregates with 8-10 nm diameters (diameter of Aβ-fibrils 10 nm) stabilized by β-sheet type hydrogen-bonding between KLVFF fragments. An artificial β-breaker molecule was designed by molecular modeling and shown to prevent efficiently aggregation of KLVFF-gelators and formation of the gels.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 098-0982904-2912
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Kemija
Upisao u CROSBI: frkanec@irb.hr (frkanec@irb.hr), 17. Ožu. 2011. u 15:28 sati



Verzija za printanje   za tiskati


upomoc
foot_4