New insights into the pathogenesis of Alzheimer's disease (CROSBI ID 571655)
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Podaci o odgovornosti
Šimić, Goran
engleski
New insights into the pathogenesis of Alzheimer's disease
The causes of Alzheimer's disease are not well understood, especially considering that more than 95% of AD patients are non-familial. Due to the similarity of brain regions affected in herpes simplex encephalitis to those mainly affected in AD, and owing to the very high prevalence of latent herpes simplex virus type 1 (HSV1) infection, reactivation of HSV1 was proposed as one of the possible causes of AD. Novel data obtained upon infection of cultured neuronal cells and mouse brain with HSV1 further show that HSV1 infection causes intracellular amyloid-beta protein accumulation, as well as abnormal phosphorylation of tau protein, the major component of tangles.
Alzheimer's disease; herpes simplex virus type 1 (HSV1); apolipoprotein E (ApoE)
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Podaci o prilogu
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Podaci o skupu
Dan hrvatsko-slovenske suradnje
pozvano predavanje
14.03.2011-14.03.2011
Ljubljana, Slovenija