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Novel imidazo[4,5-b]pyridine and triaza-benzo[c]fluorene derivatives: Synthesis, antiproliferative activity and DNA binding studies (CROSBI ID 170745)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Hranjec, Marijana ; Lučić, Borka ; Ratkaj, Ivana ; Kraljević Pavelić, Sandra ; Piantanida, Ivo ; Pavelić, Krešimir ; Karminski-Zamola, Grace Novel imidazo[4,5-b]pyridine and triaza-benzo[c]fluorene derivatives: Synthesis, antiproliferative activity and DNA binding studies // European journal of medicinal chemistry, 46 (2011), 7; 2748-2758. doi: 10.1016/j.ejmech.2011.03.062

Podaci o odgovornosti

Hranjec, Marijana ; Lučić, Borka ; Ratkaj, Ivana ; Kraljević Pavelić, Sandra ; Piantanida, Ivo ; Pavelić, Krešimir ; Karminski-Zamola, Grace

engleski

Novel imidazo[4,5-b]pyridine and triaza-benzo[c]fluorene derivatives: Synthesis, antiproliferative activity and DNA binding studies

In the present paper, we have described the synthesis and biological activity of the novel derivatives of imidazo[4, 5-b]pyridines and triaza-benzo[c]fluorenes (7-21, 24-26, 28-29). A preponderance of these compounds exerted strong cytostatic effects on the panel of seven human tumour cell lines in a dose-dependent manner. In particular, imidazo[4, 5-b]pyridines and triaza-benzo[c]fluorenes including 2-imidazolinyl derivatives showed the most potent antitumour activity. Similarly, triaza-benzo[c]fluorenes 18 and 20 induced strong growth inhibition of tested tumour cell lines, and showed low cytotoxicity in normal human fibroblasts. DNA interaction studies of these compounds demonstrated that N-methylated 16 and 2-imidazolinyl 28 triaza-benzo[c]fluorenes bind to DNA in an intercalative mode.

imidazo[4 ; 5-b]pyridines ; triaza-benzo[c]fluorenes ; antiproliferative activity ; interaction with ctDNA ; apoptosis ; cell cycle

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Podaci o izdanju

46 (7)

2011.

2748-2758

objavljeno

0223-5234

1768-3254

10.1016/j.ejmech.2011.03.062

Povezanost rada

Kemija, Temeljne medicinske znanosti

Poveznice
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