crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 508267

Časopis

Autori: Hranjec, Marijana; Lučić, Borka; Ratkaj, Ivana; Kraljević Pavelić, Sandra; Piantanida, Ivo; Pavelić, Krešimir; Karminski-Zamola, Grace
Naslov: Novel Imidazo[4, 5-b]Pyridine and Triaza-Benzo[c]Fluorene Derivatives: Synthesis, Antiproliferative Activity and DNA Binding Studies
Izvornik: European journal of medicinal chemistry (0223-5234) 46 (2011), 7; 2748-2758
Vrsta rada: članak
Ključne riječi: imidazo[4; 5-b]pyridines; triaza-benzo[c]fluorenes; antiproliferative activity; interaction with ctDNA; apoptosis; cell cycle
Sažetak:
In the present paper, we have described the synthesis and biological activity of the novel derivatives of imidazo[4, 5-b]pyridines and triaza-benzo[c]fluorenes (7-21, 24-26, 28-29). A preponderance of these compounds exerted strong cytostatic effects on the panel of seven human tumour cell lines in a dose-dependent manner. In particular, imidazo[4, 5-b]pyridines and triaza-benzo[c]fluorenes including 2-imidazolinyl derivatives showed the most potent antitumour activity. Similarly, triaza-benzo[c]fluorenes 18 and 20 induced strong growth inhibition of tested tumour cell lines, and showed low cytotoxicity in normal human fibroblasts. DNA interaction studies of these compounds demonstrated that N-methylated 16 and 2-imidazolinyl 28 triaza-benzo[c]fluorenes bind to DNA in an intercalative mode.
Projekt / tema: 125-0982464-1356, 098-0982914-2918, 335-0982464-2393, 335-0000000-3532
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S0223523411002790
Broj citata:
Altmetric:
DOI: 10.1016/j.ejmech.2011.03.062
URL cjelovitog teksta:
Google Scholar: Novel Imidazo[4, 5-b]Pyridine and Triaza-Benzo[c]Fluorene Derivatives: Synthesis, Antiproliferative Activity and DNA Binding Studies
Upisao u CROSBI: mhranjec@fkit.hr (mhranjec@fkit.hr), 30. Ožu. 2011. u 11:47 sati



  Verzija za printanje   za tiskati


upomoc
foot_4