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Autori: Levanat, Sonja; Sabol, Maja; Car, Diana; Ozretić, Petar; Musani, Vesna; Leović, Dinko
Naslov: Hh-Gli signaling pathway activity in oral squamous cell carcinoma
( Hh-Gli signaling pathway activity in oral squamous cell carcinoma )
Izvornik: Abstracts of the 36th FEBS Congress / Perham, Richard (ur.). - Oxford : Wiley-Blackwell , 2011. 241-241.
ISSN: 1742-464X
Skup: 36th FEBS Congress
Mjesto i datum: Torino, Italija, 25-30.06.2011.
Ključne riječi: Hh-Gli signaling; oral; oropharyngeal; squamous cell carcinoma; SSC
( Hh-Gli signaling; oral; oropharyngeal; squamous cell carcinoma; SSC )
Oral and oropharyngeal squamous cell carcinoma is a relatively common disease but very little is known about the molecular mechanisms responsible for cellular proliferation which include changes in p16INK4A, p53, cyclin D1, FHIT, RASSF1A, EGFR and Rb. The Hedgehog–Gli (Hh-Gli) signaling pathway plays a crucial role in vertebrate embryogenesis, while in adult organism remains active in the regulation of tissue homeostasis, regeneration and stem cell maintenance, but inappropriate activation is implicated in the development of one third of all severe cancers. The categorization of established tumors into abnormal Hh-Gli signaling that initiate tumors or in maintenance the tumor or third not yet defined category might have relevance for prognosis and targeted therapeutics. Activation of the Hh-Gli pathway begins when secreted Hedgehog (Sonic Shh, Indian Idh, or Desert Dh) binds to its receptor Patched, then inhibition of Smoothened, a G-protein coupled receptor by Patched is relieved, and activates downstream intracellular components of the pathway. The transcription of target genes (including Patched and Gli1) is subsequently activated by the Gli family of transcription factors. The role of Hh-Gli signaling pathway in squamous cell carcinoma (SCC) formation has not yet been elucidated. We found expression of main members of Hh-Gli signaling pathway, as well as activation of Survivin expression (inhibitor of apoptosis). Ptch1 was found to be correlated with p16 expression (cell cycle regulator), as well as with Survivin expression. Pathway components were associated with clinical and pathological features. Broders’ grade and N stage were associated with higher Ptch1 and lower Gli1 expression. Tumor stage was negatively associated with Smo expression, and tumor size was positively associated with p16 expression. Ptch1 and Shh were frequently detected in the surrounding stroma. Our results were confirmed in vitro in a corresponding cell line, where it was shown that the pathway is inducible by Shh protein. Our findings contribute to further understanding of the pathway in this type of tumors.
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 098-0982464-2461, 108-1080057-0043
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese:
Upisao u CROSBI: (, 11. Srp. 2011. u 14:05 sati

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