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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 52073

Časopis

Autori: Kardum, Duško; Huškić, Jasminko; Fabijanić, Damir; Banić, Marko; Buljevac, Mladen; Kujundžić Milan; Lončar, Božo
Naslov: Aktivnost serumskog angiotenzin-konvertirajućeg enzima kao tumorskog biljega za hepatocelularni karcinom
( Activity of serum angiotensin-converting enzyme as a tumour marker of hepatocellular carcinoma )
Izvornik: European journal of gastroenterology and hepatology (0954-691X) 11 (1999), 11; 1209-1213
Vrsta rada: članak
Ključne riječi: hepatocellular carcinoma; liver cirrhosis; serum angiotensin-converting enzyme activity; tumour markers
( hepatocellular carcinoma; liver cirrhosis; serum angiotensin-converting enzyme activity; tumour markers )
Sažetak:
OBJECTIVE: Previous studies have pointed to the changes of serum angiotensin-converting enzyme (SACE) values in patients with liver disease and cancer located in different sites. The aim of this study was to determine the changes in SACE values in patients with hepatocellular carcinoma (HCC) and liver cirrhosis. METHODS: The study comprised 30 patients with HCC (22 men and eight women) of average age 48.6 +/- 9.0 years and 30 patients with liver cirrhosis (21 men, nine women) of average age 49.1 +/- 9.5 years. The control group consisted of 30 healthy volunteers with matching anthropometric characteristics. SACE activity was determined by a spectrophotometric method using synthetic hippuryl-glycyl-glycine as substrate. RESULTS: The mean SACE value was considerably lower in patients with HCC, 22.8 U/ml (95% CI, 22.5-23.9), both those in whom HCC developed in cirrhotic liver (n = 23), 23.7 (22.9-24.5) as well as those with HCC without cirrhosis (n = 7), 21.8 (21.0-22.6), with regard to patients with liver cirrhosis, 37.2 (36.6-37.8) (P < 0.001). There was also a statistically significant difference between healthy, 29.9 (29.4-30.3), and both groups of HCC patients (P < 0.001). No significant differences could be found between the group of HCC patients with and without liver cirrhosis (P < 0.05). In patients with liver cirrhosis SACE value was increased in accordance with the severity of the disease expressed by Child's classification; however, at each stage SACE values were considerably lower in patients with HCC in cirrhotic liver (Child A, 35.8 vs 22.1; Child B, 38.7 vs 24.2; Child C, 40.0 vs 28.3) (P < 0.001). Alfa-fetoprotein (AFP) values did not correlate with the SACE activity. The SACE value was also significantly decreased in patients with HCC whose AFP were not altered. CONCLUSION: The study has shown that SACE values are low in patients with advanced HCC. It may be helpful in detecting HCC in patients with cirrhosis, where it can be difficult to differentiate between small HCC tumours and regeneration nodules.
Projekt / tema: 108104
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Javno zdravstvo i zdravstvena zaštita
URL cjelovitog teksta:
Google Scholar: Aktivnost serumskog angiotenzin-konvertirajućeg enzima kao tumorskog biljega za hepatocelularni karcinom



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