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Pregled bibliografske jedinice broj: 522372

Časopis

Autori: Lozić, Bernarda; Primorac, Dragan; Glavinić, Robert; Kuzmanić Šamija, Radenka; Zemunik, Tatijana
Naslov: Analysis of the C609T polymorphism of NQO1 gene in South Croatian patients with hematological malignancies
Izvornik: Collegium antropologicum (0350-6134) 35 (2011), 2; 385-388
Vrsta rada: članak
Ključne riječi: hematological malignancies; polymorphism; NQO1; clonal chromosomal abnormalities
Sažetak:
In this study we analyzed the effect of polymorphic variation of NAD(P)H: quinone oxidoreductase1 (NQO1) gene that encode enzyme which detoxifies harmful quinines and protect hematopoietic stem cells against oxidative stress. C609T polymorphism of NQO1 gene leads to loss of enzyme activity, which may be a risk factor in the etiology of specific types of hematopoietic malignancies. We analyzed C609T polymorphism in NQO1 gene in the group of 82 patients (56 adult and 26 children) with different type of hematopoietic malignancies and 99 healthy participants (61 adult and 38 children) using PCR and the RFLP method. We confirmed that the polymorphism C609T in NQO1 gene was more frequent in the adult patients' group with myeloid disorders, (p = 0.0267) compared with adult controls. We could not confirm the association C609T polymorphism with recurrent chromosome translocations (clonal karyotype changes) neither in the adult nor in pediatric group of patients.
Projekt / tema: 216-1080315-0293
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Social Science Citation Index (SSCI) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=102892
URL cjelovitog teksta:
Google Scholar: Analysis of the C609T polymorphism of NQO1 gene in South Croatian patients with hematological malignancies
Upisao u CROSBI: tzemunik@mefst.hr (tzemunik@mefst.hr), 7. Kol. 2011. u 18:01 sati



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