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Pregled bibliografske jedinice broj: 525600

Časopis

Autori: Lovaković, Tomislava; Poljak-Blaži, Marija; Duburs, Gunars; Čipak, Ana; Cindrić, Marina; Vigante, Brigita; Bisenieks, Egils; Jaganjac, Morana; Mrakovčić, Lidija; Dedić, Azra; Žarković, Neven
Naslov: Growth modulation of human cells in vitro by mild oxidative stress and 1, 4-dihydropyridine derivative antioxidants
Izvornik: Collegium antropologicum (0350-6134) 35 (2011), 1; 137-141
Vrsta rada: članak
Ključne riječi: oxidative homeostasis; growth regulation; hormesis; reactive aldehydes; HNE; bone cells
Sažetak:
Reactive oxygen species and lipid peroxidation products are not only cytotoxic but may also modulate signal transduction in cells. Accordingly, antioxidants may be considered as modifiers of cellular redox signaling. Therefore, the effects of two novel synthetic antioxidants, analogues of 1, 4-dihydropyridine derivatives, cerebrocrast and Z41-74 were analysed in vitro on human osteosarcoma cell line HOS, the growth of which can be modulated by lipid peroxidation. The cells were pretreated with either cerebrocrast or Z41-74 and afterwards exposed to mild, copper induced lipid peroxidation or to 4-hydroxynonenal (HNE), the end product of lipid peroxidation. The results obtained have shown that both antioxidants exert growth modulating effects interfering with the lipid peroxidation. Namely, cells treated with antioxidants showed increased metabolic rate and cell growth, thereby attenuating the effects of lipid peroxidation. Such biomodulating effects of cerebrocrast and Z41-74 resembled growth modulating effects of HNE, suggesting that the antioxidants could eventually promote cellular adaptation to oxidative stress interacting with redox signaling and hydroxynonenal HNE-signal transduction pathways. This may be of particular relevance for better understanding the beneficial role of hydroxynonenal HNE in cell growth control. Therefore, cerebrocrast and Z41-74 could be convenient to study further oxidative homeostasis involving lipid peroxidation.
Projekt / tema: 108-0000000-0028, 098-0982464-2519
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Social Science Citation Index (SSCI) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=97051
URL cjelovitog teksta:
Google Scholar: Growth modulation of human cells in vitro by mild oxidative stress and 1, 4-dihydropyridine derivative antioxidants
Upisao u CROSBI: mzivkovi@irb.hr (mzivkovi@irb.hr), 15. Ruj. 2011. u 14:46 sati



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