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Pregled bibliografske jedinice broj: 527463

Časopis

Autori: Dobrić, Ivan; Drviš, Petar; Petrović, Igor; Shejbal, Dražen; Brčić, Luka; Boban Blagaić, Alenka; Batelja, Lovorka; Sever, Marko; Kokić, Neven; Tonkić, Ante; Zoričić, Ivan; Miše, Sandro; Starešinić, Mario; Radić, Božo; Jakir, Ana; Babel, Jakša; Ilić, Spomenko; Vukšić, Tihomir; Jelić, Ivan; Anić, Tomislav; Seiwerth, Sven; Sikirić, Predrag
Naslov: Prolonged Esophagitis After Primary Dysfunction of the Pyloric Sphincter in the Rat and Therapeutic Potential of the Gastric Pentadecapeptide BPC 157
( Prolonged Esophagitis After Primary Dysfunction of the Pyloric Sphincter in the Rat and Therapeutic Potential of the Gastric Pentadecapeptide BPC 157 )
Izvornik: Journal of pharmacological sciences (1347-8613) 104 (2007), 1; 7-18
Vrsta rada: članak
Ključne riječi: stable gastric pentadecapeptide BPC 157; ranitidine; pyloric sphincter dysfunction; sphincter pressure; rat esophagitis
( stable gastric pentadecapeptide BPC 157; ranitidine; pyloric sphincter dysfunction; sphincter pressure; rat esophagitis )
Sažetak:
Seven or fourteen days or twelve months after suturing one tube into the pyloric sphincter (removed by peristalsis by the seventh day), rats exhibit prolonged esophagitis with a constantly lowered pressure not only in the pyloric, but also in the lower esophageal sphincter and a failure of both sphincters. Throughout the esophagitis experiment, gastric pentadecapeptide BPC 157 (PL 14736) is given intraperitoneally once a day (10 μg/kg, 10 ng/ kg, last application 24 h before assessment), or continuously in drinking water at 0.16 μg/ml, 0.16 ng/ml (12 ml / rat per day), or directly into the stomach 5 min before pressure assessment (a water manometer connected to the drainage port of a Foley catheter implanted into the stomach either through an esophageal or duodenal incision). This treatment alleviates i) the esophagitis (macroscopically and microscopically, at either region or interval), ii) the pressure in the pyloric sphincter, and iii) the pressure in the lower esophageal sphincter (cmH2O). In the normal rats it increases lower esophageal sphincter pressure, but decreases the pyloric sphincter pressure. Ranitidine, given using the same protocol (50 mg/ kg, intraperitoneally, once daily ; 0.83 mg/ml in drinking water ; 50 mg/ kg directly into the stomach) does not have an effect in either rats with esophagitis or in normal rats.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: https://www.jstage.jst.go.jp/article/jphs/104/1/104_1_7/_article
http://doi.org/10.1254/jphs.FP0061322
Broj citata:
Altmetric:
DOI: 10.1254/jphs.FP0061322
URL cjelovitog teksta:
Google Scholar: Prolonged Esophagitis After Primary Dysfunction of the Pyloric Sphincter in the Rat and Therapeutic Potential of the Gastric Pentadecapeptide BPC 157
Upisao u CROSBI: ipetrovi@kbc-zagreb.hr (ipetrovi@kbc-zagreb.hr), 27. Ruj. 2011. u 14:41 sati



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