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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 528800

Časopis

Autori: Maurac, Ivana; Sabol, Maja; Musani, Vesna; Car, Diana; Ozretić, Petar; Kalafatić, Držislav; Orešković, Slavko; Babić, Damir; Levanat, Sonja
Naslov: A low grade ovarian carcinoma case with coincident LOH of PTCH1 and BRCA1, and a mutation in BRCA1
( A low grade ovarian carcinoma case with coincident LOH of PTCH1 and BRCA1, and a mutation in BRCA1 )
Izvornik: International journal of gynecological pathology (0277-1691) 31 (2012), 3; 264-271
Vrsta rada: članak
Ključne riječi: BRCA mutation; loss of heterozygosity; Hedgehog-Gli signaling pathway; cyclopamine; primary cell culture
( BRCA mutation; loss of heterozygosity; Hedgehog-Gli signaling pathway; cyclopamine; primary cell culture )
Sažetak:
We report a case of a 53-year-old woman with grade 1 serous cystadenocarcinoma on her left ovary and metastatic serous adenocarcinoma on her right ovary. Serous carcinoma is the most common type of ovarian cancer, representing approximately half of all cases. Due to positive family history, patient was referred to BRCA1/2 screening. Germline BRCA1 mutation c.676delT (p.C226VfsX8) was found, and in tumor tissue the normal allele was lost. Tumor tissue also had loss of heterozygosity in the PTCH1 gene, one of the major members of the Hedgehog-Gli (Hh-Gli) pathway. Gene expression analysis showed upregulation of the Hh-Gli pathway in both ovaries, compared to healthy ovarian tissue. Primary cell culture was developed from the patient’s tissue and showed downregulation of gene expression in response to cyclopamine, Hh-Gli pathway inhibitor. The Hh-Gli signaling pathway may play a role in malignant transformation and metastasis of ovarian cancer.
Projekt / tema: 098-0982464-2461
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://journals.lww.com/intjgynpathology/Abstract/2012/05000/A_Low_grade_Ovarian_Carcinoma_Case_With_Coincident.10.aspx
Broj citata:
Altmetric:
DOI: 10.1097/PGP.0b013e31823b6f0f
URL cjelovitog teksta:
Google Scholar: A low grade ovarian carcinoma case with coincident LOH of PTCH1 and BRCA1, and a mutation in BRCA1
Upisao u CROSBI: mcretnik@irb.hr (mcretnik@irb.hr), 5. Lis. 2011. u 11:32 sati



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