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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 529573

Časopis

Autori: Tišlarić-Medenjak, Dubravka; Košec, Vesna; Tonković-Đurišević, Ivana; Zec, Ivana; Sabolović- Rudman, Senka; Kuna, Krunoslav; Herman, Radoslav; Ivičević-Bakulić, Tomislav; Soljačić-Vraneš, Hrvojka; Tučkar, Neven; Mužinić, Dubravka; Butorac, Dražan; Bolanča, Ivan; Košec, Andro; Stipoljev, Feodora
Naslov: Biochemical Screening of Fetal Aneuploidies and Neural Tube Defects by »Double-Test« in Croatia: A 10 Years’ Experience
( Biochemical Screening of Fetal Aneuploidies and Neural Tube Defects by »Double-Test« in Croatia: A 10 Years’ Experience )
Izvornik: Collegium Antropologicum (0350-6134) 35 (2011), 3; 957-962
Vrsta rada: pregledni rad
Ključne riječi: Down syndrome screening; second-trimester; alpha-fetoprotein; hCG free beta-subunit; fetal aneuplodies; neural tube defects
( Down syndrome screening; second-trimester; alpha-fetoprotein; hCG free beta-subunit; fetal aneuplodies; neural tube defects )
Sažetak:
The aim of the study is to investigate the efficiency of the second-trimester biochemical screening, with maternal serum alpha-fetoprotein (MS-AFP) and free beta-subunit of human chorionic gonadotropin (free beta-hCG), during the ten-year period. The study included 11, 292 of pregnant women between the 15th and 18th gestational week, who underwent screening from November 1996 to December 2006. The risk for trisomy 21 and trisomy 18 were calculated by computer software, based on a model which generated the final risk for fetal aneuploidies from the pregnant woman’s a priori age risk and the likelihood ratio of the distribution of the biochemical markers, according to the second-trimester gestation. With the cut- off value of the final risk 1:250, the detection rate for trisomy 21 was 75% (21/28). In women less than or equal to 35, the detection was 57.1% (8/14) and 92.9% (13/14) in those over 35 years, respectively. The detection rate of trisomy 18 was 50% (2/4). The results confirmed that the implementation of double-test, as non-invasive screening for fetal aneuploidies, should be accepted as a complementary method of antenatal care.
Projekt / tema: 108-1080399-0383
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Social Science Citation Index (SSCI) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti,Javno zdravstvo i zdravstvena zaštita
URL Internet adrese: http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=107485
URL cjelovitog teksta:
Google Scholar: Biochemical Screening of Fetal Aneuploidies and Neural Tube Defects by »Double-Test« in Croatia: A 10 Years’ Experience
Upisao u CROSBI: tislaric@kbcsm.hr (tislaric@kbcsm.hr), 10. Lis. 2011. u 11:34 sati



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