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Pregled bibliografske jedinice broj: 529590

Časopis

Autori: Zec, Ivana; Tišlarić-Medenjak, Dubravka; Bukovec Megla, Željka; Kučak, Ivana
Naslov: Anti-Müllerian hormone: A unique biochemical marker of gonadal development and fertility in humans
( Anti-Müllerian hormone: A unique biochemical marker of gonadal development and fertility in humans )
Izvornik: Biochemia medica : časopis hrvatskoga društva medicinskih biokemičara (1330-0962) 21 (2011), 3; 219-230
Vrsta rada: pregledni rad
Ključne riječi: anti-Müllerian hormone; ovarian reserve; spermatogenesis; infertility; sex-differentiation
( anti-Müllerian hormone; ovarian reserve; spermatogenesis; infertility; sex-differentiation )
Sažetak:
Anti-Müllerian hormone (AMH) is a glycoprotein belonging to the transforming growth factors (TGF- β). AMH plays a fundamental role in the regression of Müllerian ducts in male embryo. In its absence, Müllerian ducts develop in to female inner reproductive organs. In boys, it is significantly produced in Sertoli cells of testes until puberty and then slowly decreases to residual values for the rest of the men’s life. AMH serves as a biochemical marker of the presence of testes in cryptorchidic males. In females, AMH is secreted by granulosa cells of small follicles in the ovary. Serum values are almost undetectable during infancy and then rapidly increase with the onset of puberty, reflecting the initial recruitment of primordial follicles. AMH is produced in growing follicles until they reach a stage when dominant follicle is detached from a cohort of antral follicles. The measurement of serum AMH levels during woman’s reproductive life represents an ideal tool for the assessment of the ovarian follicular reserve. The advantage of AMH in relation to the ovarian steroid hormones is that serum levels do not fluctuate significantly during the menstrual cycle. In addition, circulating AMH strongly correlates with antral follicle count (AFC), visualized by ultrasound in the follicular phase of the cycle. As the number and quality of the oocytes diminish throughout the woman’s reproductive life, serum concentrations of AMH gradually decrease and fall below detectable levels in menopause. This could be of particular interest in subfertile and infertile women undergoing assisted reproductive techniques (ART) in achieving pregnancy.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Ostalo
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: http://www.biochemia-medica.com/content/213-199-338
http://www.biochemia-medica.com/content/213-199-338
URL cjelovitog teksta:
Google Scholar: Anti-Müllerian hormone: A unique biochemical marker of gonadal development and fertility in humans
Upisao u CROSBI: tislaric@kbcsm.hr (tislaric@kbcsm.hr), 10. Lis. 2011. u 12:07 sati



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