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Pregled bibliografske jedinice broj: 531304

Časopis

Autori: Mirošević Skvrce, Nikica; Macolić Šarinić, Viola; Mucalo, Iva; Krnić, Darko; Tomić, Siniša
Naslov: Adverse drug reactions caused by drug-drug interactions reported to Croatian Agency for Medicinal Products and Medical Devices: a retrospective observational study
( Adverse drug reactions caused by drug-drug interactions reported to Croatian Agency for Medicinal Products and Medical Devices: a retrospective observational study )
Izvornik: Croatian medical journal (0353-9504) 52 (2011), 5; 604-614
Vrsta rada: članak
Ključne riječi: drug-drug interactions; adverse drug reactions; adverse drug reaction reporting systems; anticoagulants; platelet aggregation inhibitors; non-steroidal anti-inflammatory agents; central nervous system agents; peripheral nervous system agents
( drug-drug interactions; adverse drug reactions; adverse drug reaction reporting systems; anticoagulants; platelet aggregation inhibitors; non-steroidal anti-inflammatory agents; central nervous system agents; peripheral nervous system agents )
Sažetak:
Aim was to analyze potential and actual drug-drug interactions reported to the Spontaneous Reporting Database of the Croatian Agency for Medicinal Products and Medical Devices (HALMED) and determine their incidence. In this retrospective observational study performed from March 2005 to December 2008, we detected potential and actual drug-drug interactions using interaction programs and analyzed them. HALMED received 1209 reports involving at least two drugs. There were 468 (38.7%) reports on potential drug-drug interactions, 94 of which (7.8% of total reports) were actual drug-drug interactions. Among actual drug drug interaction reports, the proportion of serious adverse drug reactions (53 out of 94) and the number of drugs (n = 4) was significantly higher (P < 0.001) than among the remaining reports (580 out of 1982 ; n = 2, respectively). Actual drug-drug interactions most frequently involved nervous system agents (34.0%), and interactions caused by antiplatelet, anticoagulant, and non-steroidal anti-inflammatory drugs were in most cases serious. In only 12 out of 94 reports, actual drug-drug interactions were recognized by the reporter. The study confirmed that the Spontaneous Reporting Database was a valuable resource for detecting actual drug-drug interactions. Also, it identified drugs leading to serious adverse drug reactions and deaths, thus indicating the areas which should be in the focus of health care education.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti,Farmacija
URL Internet adrese: http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=110101
Broj citata:
Altmetric:
DOI: 10.3325/cmj.2011.52.604
URL cjelovitog teksta:
Google Scholar: Adverse drug reactions caused by drug-drug interactions reported to Croatian Agency for Medicinal Products and Medical Devices: a retrospective observational study
Upisao u CROSBI: ijankovic@pharma.hr (ijankovic@pharma.hr), 21. Lis. 2011. u 10:28 sati



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