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Pregled bibliografske jedinice broj: 533149

Zbornik radova

Autori: Habuš, Josipa; Mojčec, Vesna; Štritof, Zrinka; Milas, Zoran; Starešina, Vilim; Tadin, Ante; Markotić, Alemka; Beck, Relja; Margaletić, Josip; Vucelja, Marko; Bjedov, Linda; Turk, Nenad
Naslov: Rodents as reservoirs of multiple pathogens - is one etiological diagnosis enough?
( Rodents as reservoirs of multiple pathogens - is one etiological diagnosis enough? )
Izvornik: Abstracts of the VIIth Meeting of the International Leptospirosis Society
Skup: Meeting of the International Leptospirosis Society (7 ; 2011)
Mjesto i datum: Merida, Meksiko, 19.-22.09.2011.
Ključne riječi: leptospira; babesia; hantaviruses; rodents
( leptospira; babesia; hantaviruses; rodents )
Sažetak:
During the copious study of leptospirosis epidemiology in a northwest Croatia a forest area was found with the highest Leptospira isolation rate (30.4%) reported. High density of rodents accompanied with high infection rates was considered as a possible public health threat. Moreover, increase in rodent abundance indicated the possible presence of other rodent-borne pathogens. Rodents as reservoirs of multiple pathogens could represent high risk for multiple infections in humans that can lead to severe clinical picture, often with non-specific symptoms making diagnosis more difficult. We investigated part of the captured animals on presence for Leptospira spp., Hantaviruses and B. microti. Leptospira isolates were typed by MAT to the serogroup level using a panel of 41 rabbit anti-Leptospira reference antisera. Subsequent typing of the isolates to the serovar level was performed by MAT with panels of monoclonal antibodies (mAbs). Genomospecies were identified as previously described (1, 2). A specific 186 bp of DOBV M genome segment and specific 97 bp segment within the PUUV S genome segment was detected by real-time RT-PCR (3, 4). B. microti was detected by amplification of a 560 bp fragment of the small subunit ribosomal RNA gene (5). Out of 44 renal cultures 13 (30%) Leptospira spp. isolates were obtained ; 12 (92 %) of them were identified as L. interrogans, serogroup Australis while one isolate (8 %) was identified as L. kirschneri, serogroup Grippotyphosa, serovar Dadas. Presence of Hantavirus RNA was confirmed in 23 rodents (52 %) – DOBV in 20 (87 %) and PUUV in three (13%) while B. microti DNA was detected in six rodents (14%). Infection with all three pathogens was found in three rodents (7 %), dual infection with Hantavirus and Leptospira in seven rodents (16 %), dual infection with Hantavirus and Babesia in two rodents (5 %) and another dual infection with Leptospira and Babesia in one rodent (2 %), Multiple co-infections with interestingly high infection rates of Leptospira spp. and Hantavirus were found in the same rodent population from a relatively small investigated area. Possible explanation could be found in fluctuation in abundance of reservoir species or specific characteristics of a certain habitat. Further identification of potential temporal risk zones could help understand the transmission dynamics of the disease and formulate adequate
Vrsta sudjelovanja: Predavanje
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Nema recenziju
Projekt / tema: 053-0481153-1129, 053-1430115-2116, 143-1430115-0103, 068-1430115-2119
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Javno zdravstvo i zdravstvena zaštita,Veterinarska medicina
Upisao u CROSBI: jhabus@vef.hr (jhabus@vef.hr), 2. Stu. 2011. u 11:47 sati



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