crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 534798

Časopis

Autori: Vidović, Anđelko; Grubišić-Ilić, Mirjana; Kozarić-Kovačić, Dragica; Gotovac, Katja; Rakoš, Iva; Markotić, Alemka; Rabatić, Sabina; Dekaris, Dragan; Sabioncello, Ante
Naslov: Exaggerated platelet reactivity to physiological agonists in war veterans with posttraumatic stress disorder
( Exaggerated platelet reactivity to physiological agonists in war veterans with posttraumatic stress disorder )
Izvornik: Psychoneuroendocrinology (0306-4530) 36 (2011), 2; 161-172
Vrsta rada: članak
Ključne riječi: PTSD; platelet activation; platelet aggregation; leukocyte; epinephrine; ADP
( PTSD; platelet activation; platelet aggregation; leukocyte; epinephrine; ADP )
Sažetak:
An association between traumatic stress and cardiovascular disease (CVD) is supported by various epidemiological studies. Platelet activation and binding of activated platelets to leukocytes contributes to the pathophysiology of CVD. Evidence of hyperactive sympathetic nervous system, altered expression of platelet alpha2-adrenoreceptors (alpha2AR), and altered platelet adenylate cyclase activity in patients with posttraumatic stress disorder (PTSD) suggest that platelet reactivity in PTSD may be altered as well. We tested whether platelet reactivity to increasing doses of adenosine-diphosphate (ADP), epinephrine (EPI), or their combination differs between war veterans with PTSD (n = 15) and healthy controls (n = 12). For this purpose, citrated whole blood was incubated with increasing concentrations of ADP (0.1, 1, 10 microM), EPI alone (10 nM, 100 nM, 1000 nM), or EPI (10 nM, 100 nM, 1000 nM) in combination with 0.1 microM ADP. A subset of samples was also incubated with 10 microM yohimbine (YOH), alpha2AR antagonist, to distinguish receptor-specific effects. Platelet CD62P expression and formation of platelet—leukocyte aggregates (PLA) [platelet—monocyte (P—Mo), —lymphocyte (P—Ly), and —neutrophil (P—Ne) aggregates] were measured using three-color flow cytometry. Platelet reactivity was higher in war veterans with PTSD when compared to controls, as determined by greater CD62P expression and formation of PLA in response to ADP alone or in combination with EPI. Platelet reactivity also correlated with the severity of PTSD symptoms. Preliminary experiments with YOH indicate that stress-associated EPI elevations may contribute to platelet activation through a alpha2AR-dependent mechanism. The enhanced platelet reactivity observed in our study may be the underlying mechanism contributing to the development of CVD in PTSD patients.
Projekt / tema: 021-0212432-2434, 198-1081870-0074, 198-0982522-0075
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S0306453010002131
Broj citata:
Altmetric:
DOI: 0.1016/j.psyneuen.2010.08.005
URL cjelovitog teksta:
Google Scholar: Exaggerated platelet reactivity to physiological agonists in war veterans with posttraumatic stress disorder
Upisao u CROSBI: asabioncello@imz.hr (asabioncello@imz.hr), 8. Stu. 2011. u 11:33 sati



  Verzija za printanje   za tiskati


upomoc
foot_4