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Pregled bibliografske jedinice broj: 536047

Časopis

Autori: Wain L.V.; ...; Polašek, Ozren; Boban, Mladen; ...; Rudan, Igor; ...; van Duijn, Cornelia M.
Naslov: Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
( Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure )
Izvornik: Nature genetics (1061-4036) 43 (2011), 10; 1005-1011
Vrsta rada: pismo
Ključne riječi: pulse pressure; mean arterial pressure; genome-wide
( pulse pressure; mean arterial pressure; genome-wide )
Sažetak:
Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74, 064) and follow-up studies (N = 48, 607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.
Projekt / tema: 216-1080315-0302
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Javno zdravstvo i zdravstvena zaštita
URL Internet adrese: http://www.nature.com/ng/journal/v43/n10/full/ng.922.html
Broj citata:
Altmetric:
DOI: 10.1038/ng.922
URL cjelovitog teksta:
Google Scholar: Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
Upisao u CROSBI: opolasek@mefst.hr (opolasek@mefst.hr), 10. Stu. 2011. u 06:31 sati



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