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Pregled bibliografske jedinice broj: 539203

Časopis

Autori: Perletti, G; Škerk, Višnja; Magri, V; Markotić, Alemka; Mazzoli, S; Parnham, MJ; Wagenlehner, FM; Naber, KG
Naslov: Macrolides for the treatment of chronic bacterial prostatitis: an effective application of their unique pharmacokinetic and pharmacodynamic profile (Review)
( Macrolides for the treatment of chronic bacterial prostatitis: an effective application of their unique pharmacokinetic and pharmacodynamic profile (Review) )
Izvornik: Molecular medicine report (1791-2997) 4 (2011), 6; 1035-1044
Vrsta rada: članak
Ključne riječi: prostatitis; macrolides; azithromycin; biofilm; Chlamydia trachomatis; urological infections; sexually-transmitted infections
( prostatitis; macrolides; azithromycin; biofilm; Chlamydia trachomatis; urological infections; sexually-transmitted infections )
Sažetak:
Chronic bacterial prostatitis (CBP) is a persistent infection of the prostate characterized by poor quality of life mainly due to frequent relapse episodes caused by incomplete eradication of causative pathogens. Aggressive antibacterial therapy is required to attenuate the severe symptoms of CBP and to achieve a permanent cure. Although fluoroquinolones are currently recommended as first-choice agents, macrolide antibiotics are emerging as a noteworthy option for the treatment of CBP. Macrolide antibiotics are characterized by an impressive array of distinct pharmacokinetic (PK) and pharmacodynamic (PD) properties. These properties include high intracellular accumulation in phagocytes and at sites of infection, including the prostate ; broad antibiotic but also biofilm-inhibiting properties ; immunomodulating and inflammation-resolving activities. These features offer particular advantages for the treatment of chronic infections of the prostate gland, which are not easily amenable to drug therapy. Macrolides may be exploited to counteract the unsatisfactory rates of clinical symptom improvement and pathogen eradication. The results of a number of clinical trials support this proposal.
Projekt / tema: 143-1080002-0050, 143-1430115-0103
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL cjelovitog teksta:
Časopis izlazi u samo elektroničkom izdanju: NE
Google Scholar: Macrolides for the treatment of chronic bacterial prostatitis: an effective application of their unique pharmacokinetic and pharmacodynamic profile (Review)
Upisao u CROSBI: mfijucek@bfm.hr (mfijucek@bfm.hr), 14. Stu. 2011. u 14:03 sati



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