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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 541678

Časopis

Autori: Cvetko Krajinović, Lidija; Šoprek, Silvija; Korva, Miša; Dželalija, Boris; Đaković Rode, Oktavija; Škerk, Višnja; Avšič-Županc, Tatjana; Markotić, Alemka
Naslov: Serum levels of metalloproteinases and their inhibitors during infection with pathogens having integrin receptor-mediated cellular entry
( Serum levels of metalloproteinases and their inhibitors during infection with pathogens having integrin receptor-mediated cellular entry )
Izvornik: Scandinavian journal of infectious diseases (0036-5548) 44 (2012), 9; 663-669
Vrsta rada: članak
Ključne riječi: metalloproteinases; integrin-receptors
( metalloproteinases; integrin-receptors )
Sažetak:
Background: Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes with numerous roles in the normal immune response to infection. However, excess MMP activity following infection may lead to immunopathological processes that cause tissue damage. Their activity in normal tissues is subject to tight control, which is regulated by its specifi c endogenous tissue inhibitors (TIMPs). It is known that MMPs bind to cell surface proteins (e.g. integrins) and that such interactions can have modulatory effects on MMP functionality. The objective of this study was to determine whether there are differences in MMP and TIMP production during the acute phase of infection with different pathogens that use β -integrins as their receptors for cell entry. Methods: We measured the total amounts of soluble MMP-2, MMP-9, TIMP-1, and TIMP-2 in the sera from patients infected with Dobrava virus (DOBV), Coxiella burnetii, or uropathogenic Escherichia coli. Statistical analyses were used to correlate MMP/TIMP serum levels with different clinical laboratory parameters. Results: The results showed that both of the bacterial infections generally manifested the stronger effect on MMP production, while in contrast, viral infection introduced stronger changes to metalloproteinase inhibitors. MMPs and TIMPs were signifi cantly correlated with some of the clinical laboratory parameters in both bacterial infections, but no correlations were found for DOBV infection. Conclusions: These fi ndings suggest diverse mechanisms by which MMP activity could be implicated in the pathology of these 2 bacterial infections versus the viral DOBV infection, despite the type of their cellular entry receptors.
Projekt / tema: 143-1080002-0050, 143-1430115-0103
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://www.ingentaconnect.com/content/apl/sinf/2012/00000044/00000009/art00004
http://dx.doi.org/10.3109/00365548.2012.677060
Broj citata:
Altmetric:
DOI: 10.3109/00365548.2012.677060
URL cjelovitog teksta:
Google Scholar: Serum levels of metalloproteinases and their inhibitors during infection with pathogens having integrin receptor-mediated cellular entry
Upisao u CROSBI: apavelic@bfm.hr (apavelic@bfm.hr), 16. Stu. 2011. u 13:01 sati



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