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Pregled bibliografske jedinice broj: 541920

Zbornik radova

Autori: Cvetko Krajinović, Lidija; Šoprek, Silvija; Korva, Miša; Dželalija, Boris; Đaković Rode, Oktavija; Škerk, Višnja; Avšič Županc, Tatjana; Markotić, Alemka
Naslov: Serum levels of metalloproteinases and their inhibitors during the infection with pathogens having integrin-receptors mediated cellular entry
( Serum levels of metalloproteinases and their inhibitors during the infection with pathogens having integrin-receptors mediated cellular entry )
Izvornik: Book of abstracts - 2011 Annual Meeting of the Croatian Immunological Society
Skup: 2011 Annual Meeting of the Croatian Immunological Society
Mjesto i datum: Rabac, Hrvatska, 7.-9. listopada 2011.
Ključne riječi: Matrix metalloproteinases; integrin receptors; Dobrava virus; Coxiella burnetii; Escherichia coli
( Matrix metalloproteinases; integrin receptors; Dobrava virus; Coxiella burnetii; Escherichia coli )
Sažetak:
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes whose numerous roles are found in the normal immune response to infection. However, excess MMP activity following infection may lead to immunopathological processes that cause tissue damage. Expression, secretion, and activity of MMPs in normal tissues are subject to tight control which is regulated by its specific endogenous tissue inhibitors (TIMPs). It is known that MMPs bind to cell surface proteins (e.g. integrin receptors), and such interactions can have modulatory effects on MMP functionality. The objective of this study was to test whether there are some differences in MMP and TIMP production during the acute infection with different pathogens using β integrins as their receptors for the cell entry. We measured total amounts of soluble MMP-2, MMP-9, TIMP-1, and TIMP-2 in the sera from patients infected with Dobrava virus (DOBV) and Coxiella burnetii (representatives of β3 integrin cell entry) or uropathogenic Escherichia coli (representative of β1 integrin cell entry). Statistical analyses were used to correlate MMP/TIMP serum levels with different biochemical parameters. The results showed that both bacterial infections generally manifested the stronger effect on MMPs production while, in contrast, viral infection introduced stronger changes on metalloproteinase inhibitors. MMPs and TIMPs significantly correlated with some of biochemical parameters in both bacterial infections but no correlations were found in DOBV infection. This could suggest diverse mechanisms by which MMP activity could be implicated in pathology of these two bacterial infections versus viral, DOBV infection despite their cellular entry receptors.
Vrsta sudjelovanja: Predavanje
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 143-1430115-0103, 143-1080002-0050
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti,Javno zdravstvo i zdravstvena zaštita
Upisao u CROSBI: apavelic@bfm.hr (apavelic@bfm.hr), 16. Stu. 2011. u 14:31 sati



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