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Pregled bibliografske jedinice broj: 542311

Časopis

Autori: Casós, Kelly; Zaragozá, María C.; Žarković, Neven; Žarković, Kamelija; Andrišić, Luka; Portero-Otín, Manuel; Cacabelo, Daniel; Mitjavil, María T.
Naslov: A fish oil-rich diet reduces vascular oxidative stress in apoE–/– mice
Izvornik: Free radical research (1071-5762) 44 (2010), 7; 821-829
Vrsta rada: članak
Ključne riječi: atherosclerosis; 4-hydroxynonenal; polyunsaturated fatty acids; nitric oxide; superoxide anion; aortic root
Sažetak:
Oxidative stress contributes to lipid peroxidation and decreases nitric oxide (NO) bioavailability in atherosclerosis. While long-chain (n-3) polyunsaturated fatty acids (PUFA) are easily oxidized in vitro, they improve endothelial function. Hence, this study postulates that long-chain (n-3) PUFA decrease atherogenic oxidative stress in vivo. To test this, apoE–/– mice were fed a corn oil- or a fish oil (FO)-rich diet for 8, 14 or 20 weeks and parameters related to NO and superoxide (O2.–) plus markers of lipid peroxidation and protein oxidative damage in the aortic root were evaluated. The FO-rich diet increased NO production and endothelial NO synthase (NOS) expression and lowered inducible NOS, p22phox expression and O2.–production after 14 and 20 weeks of diet. Protein lipoxidative damage (including 4-hydroxynonenal) was decreased after a long-term FO-diet. This supports the hypothesis that a FO-rich diet could counteract atherogenic oxidative stress, showing beneficial effects of long-chain (n-3) PUFA.
Projekt / tema: 108-0000000-0028, 098-0982464-2519
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
URL Internet adrese: http://informahealthcare.com/doi/abs/10.3109/10715762.2010.485992
Broj citata:
Altmetric:
DOI: 10.3109/10715762.2010.485992
URL cjelovitog teksta:
Google Scholar: A fish oil-rich diet reduces vascular oxidative stress in apoE–/– mice
Upisao u CROSBI: mstroser@mef.hr (mstroser@mef.hr), 16. Stu. 2011. u 19:44 sati



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