Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

A fish oil-rich diet reduces vascular oxidative stress in apoE–/– mice (CROSBI ID 176946)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Casós, Kelly ; Zaragozá, María C. ; Žarković, Neven ; Žarković, Kamelija ; Andrišić, Luka ; Portero-Otín, Manuel ; Cacabelo, Daniel ; Mitjavil, María T. A fish oil-rich diet reduces vascular oxidative stress in apoE–/– mice // Free radical research, 44 (2010), 7; 821-829. doi: 10.3109/10715762.2010.485992

Podaci o odgovornosti

Casós, Kelly ; Zaragozá, María C. ; Žarković, Neven ; Žarković, Kamelija ; Andrišić, Luka ; Portero-Otín, Manuel ; Cacabelo, Daniel ; Mitjavil, María T.

engleski

A fish oil-rich diet reduces vascular oxidative stress in apoE–/– mice

Oxidative stress contributes to lipid peroxidation and decreases nitric oxide (NO) bioavailability in atherosclerosis. While long-chain (n-3) polyunsaturated fatty acids (PUFA) are easily oxidized in vitro, they improve endothelial function. Hence, this study postulates that long-chain (n-3) PUFA decrease atherogenic oxidative stress in vivo. To test this, apoE–/– mice were fed a corn oil- or a fish oil (FO)-rich diet for 8, 14 or 20 weeks and parameters related to NO and superoxide (O2.–) plus markers of lipid peroxidation and protein oxidative damage in the aortic root were evaluated. The FO-rich diet increased NO production and endothelial NO synthase (NOS) expression and lowered inducible NOS, p22phox expression and O2.–production after 14 and 20 weeks of diet. Protein lipoxidative damage (including 4-hydroxynonenal) was decreased after a long-term FO-diet. This supports the hypothesis that a FO-rich diet could counteract atherogenic oxidative stress, showing beneficial effects of long-chain (n-3) PUFA.

atherosclerosis; 4-hydroxynonenal; polyunsaturated fatty acids; nitric oxide; superoxide anion; aortic root

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

44 (7)

2010.

821-829

objavljeno

1071-5762

10.3109/10715762.2010.485992

Povezanost rada

nije evidentirano

Poveznice
Indeksiranost