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Pregled bibliografske jedinice broj: 542327

Časopis

Autori: Ilić, Spomenko; Drmić, Domagoj; Franjić, Sandra; Kolenc, Danijela; Ćorić, Marijana; Brčić, Luka; Kliček, Robert; Radić, Božo; Sever, Marko; Đuzel, Viktor; Filipović, Marinko; Đaković, Željko; Stambolija, Vasilije; Boban Blagaić, Alenka; Zoričić, Ivan; Gjurašin, Miroslav; Stupnišek, Mirjana; Romić, Željko; Žarković, Kamelija; Džidić, Senka; Seiwerth, Sven; Sikirić, Predrag
Naslov: Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model : Diclofenac-induced gastrointestinal, liver, and encephalopathy lesions
Izvornik: Life sciences (0024-3205) 88 (2011), 11/12; 535-542
Vrsta rada: članak
Ključne riječi: BPC 157; diclofenac; NSAIDs; toxicity; rats
Sažetak:
We attempted to fully antagonize the extensive toxicity caused by NSAIDs (using diclofenac as a prototype). Herein, we used the stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, MW 1419), an anti-ulcer peptide shown to be efficient in inflammatory bowel disease clinical trials (PL 14736) and various wound treatments with no toxicity reported. This peptide was given to antagonize combined gastrointestinal, liver, and brain toxicity induced by diclofenac (12.5 mg/kg intraperitoneally, once daily for 3 days) in rats. Key findings Already considered a drug that can reverse the toxic side effects of NSAIDs, BPC 157 (10 μg/kg, 10 ng/kg) was strongly effective throughout the entire experiment when given (i) intraperitoneally immediately after diclofenac or (ii) per-orally in drinking water (0.16 μg/mL, 0.16 ng/mL). Without BPC 157 treatment, at 3 h following the last diclofenac challenge, we encountered a complex deleterious circuit of diclofenac toxicity characterized by severe gastric, intestinal and liver lesions, increased bilirubin, aspartate transaminase (AST), alanine transaminase (ALT) serum values, increased liver weight, prolonged sedation/unconsciousness (after any diclofenac challenge) and finally hepatic encephalopathy (brain edema particularly located in the cerebral cortex and cerebellum, more in white than in gray matter, damaged red neurons, particularly in the cerebral cortex and cerebellar nuclei, Purkinje cells and less commonly in the hippocampal neurons). The very extensive antagonization of diclofenac toxicity achieved with BPC 157 (μg-/ng-regimen, intraperitoneally, per-orally) may encourage its further use as a therapy to counteract diclofenac- and other NSAID-induced toxicity.
Projekt / tema: 108-1083570-3634, 108-0532264-0048, 098-0982464-2519, 108-1083570-3643, 108-1083570-3635, 108-0000000-0028
Izvorni jezik: ENG
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bazama podataka:
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MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
URL Internet adrese: http://dx.doi.org/10.1016/j.lfs.2011.01.015
http://ac.els-cdn.com/S002432051100035X/1-s2.0-S002432051100035X-main.pdf?_tid=fc04734a-f360-11e1-8edb-00000aacb360&acdnat=1346413546_1e3692b65fa9d71beb1eea01e74b9697
http://www.sciencedirect.com/science/article/pii/S002432051100035X
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DOI: 10.1016/j.lfs.2011.01.015
URL cjelovitog teksta: http://dx.doi.org/10.1016/j.lfs.2011.01.015
Google Scholar: Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model : Diclofenac-induced gastrointestinal, liver, and encephalopathy lesions
Upisao u CROSBI: mstroser@mef.hr (mstroser@mef.hr), 16. Stu. 2011. u 20:05 sati



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