crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 543634

Zbornik radova

Autori: Cvetko Krajinović, Lidija; Šoprek, Silvija; Đaković Rode, Oktavija; Markotić, Alemka
Naslov: Serum levels of metalloproteinases and their inhibitors during the infection with pathogens having integrin-receptors mediated cellular entry
( Serum levels of metalloproteinases and their inhibitors during the infection with pathogens having integrin-receptors mediated cellular entry )
Izvornik: Program & Abstract Book - The 8th International Conference on HFRS, HPS & Hantaviruses / Papa, Anna ; Antoniadis, Antonis (ur.). - Atena : International Society for Hantaviruses and Hantaviral Diseases , 2010. 203 (ISBN: 5-256-54411-2).
Skup: The 8th International Conference on HFRS, HPS & Hantaviruses
Mjesto i datum: Atena, Grčka, 20.-22.05.2010.
Ključne riječi: Matrix metalloproteinases; integrin receptors; Dobrava virus; Coxiella burnetii; Escherichia coli
( Matrix metalloproteinases; integrin receptors; Dobrava virus; Coxiella burnetii; Escherichia coli )
Sažetak:
Pathogenic hantaviruses use β3 and non-pathogenic β1 integrins as their receptors and primary invade vascular endothelium leading to its damage, increased endothelial permeability and vascular damage. The major enzymes involved in degradation of matrix components belong to the matrix metalloproteinase (MMP) family. It has been reported that integrins interact with some MMPs and that such interactions might regulate MMP functionality in human endothelial cells. Our objective was to study whether there are some differences in production of MMPs and thier tissue inhibitors (TIMPs) in patients sera, during the infection with different pathogens using β3 and β1 integrins as their receptors for the cellular entry. We measured MMP-2, MMP-9, TIMP-1, and TIMP-2 in sera of patients infected with Dobrava virus (DOBV) and Coxiella burnetii (COX), representatives of β3 integrin cell entry, or Escherichia coli (ECOLI), representative of β1 integrin cell entry. All three considered microorganisms induced changes in MMP/TIMPs serum levels. Some differences were observed between DOBV influence on MMP/TIMPs in comparisom to COX and ECOLI, while no differences were detected regarding integrin-receptors (β1 or β3) mediated cellular entry.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 143-1430115-0103
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti,Javno zdravstvo i zdravstvena zaštita
Upisao u CROSBI: apavelic@bfm.hr (apavelic@bfm.hr), 17. Stu. 2011. u 15:55 sati



Verzija za printanje   za tiskati


upomoc
foot_4