engleski

Human arterial hypertension revisited: How to leap from animal models to individually tailored therapy?

During several decades research on arterial hypertension focused on several issues: kidney perfusion in Goldblat's hypertension, dietary salt intake and renal excretion, roles of atrial and other natriuretic factors, increased exposure to vasoconstrictors (norepinephrine, epinephrine, vasopressin, angiotensin II, endothelin-I), reduced local vasodilatatory actions (nitric oxide, adenosine etc.). Recent advancement of molecular biology turned our attention to intracellular mechanisms and gene expression.

arterial hypertension; human medicine; animal models; epidemiology; dementia; high fructose corn syrup

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