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Pregled bibliografske jedinice broj: 545317


Autori: Kurelac, Ivan; Papić, Neven; Sakoman, Slavko; Orban, Mirjana; Dušek, Davorka; Ćorić, Marijana; Vince, Adriana
Naslov: Intravenous Drug Users Can Achieve a High Sustained Virological Response Rate : Experience From Croatian Reference Center for Viral Hepatitis
Izvornik: Hepatitis Monthly (1735-143X) 11 (2011), 12; 986-992
Vrsta rada: članak
Ključne riječi: addiction; intravenous drug users; viral hepatitis; chronic hepatitis C; antiviral therapy
Hepatitis C virus (HCV) is the major infectious disease agent among injecting drug users (IVDUs). However, most of the IVDUs are still excluded from the treatment. The aim of this study was to examine the treatment course, adherence, tolerability and safety profiles and SVR rates in IVDUs compared to non-IVDUs. Demographic and clinical data were collected from medical records of 345 adult patients diagnosed with chronic hepatitis C (CHC) who were treated with a PEG-IFN-α and ribavirin in Croatian Reference Center for Viral Hepatitis in Zagreb in period between January 2003 and January 2010. Efficacy, safety and tolerability treatment profiles were analyzed in IVDUs versus non IVDUs. Positive predictors for treatment outcome were evaluated by univariate and multivariate logistic regression. A total of 106 (30.46%) IVDUs were recognized. The IVDUs were characterized by predominated male sex (81.13% vs. 52.30%, p=0.0001), younger age (32.46±5.33y vs. 46.12±11.48y, p=0.0001), lower fibrosis and HAI score (measured by ISHAK) and shorter duration of infection (8.98±5.87 vs. 16.79±8.99y, p=0.0001) than non-IVDU group. In IVDUs genotype 1a (24.52%) and 3a (38.68%) were predominant. There were no differences in completion rate between two groups. IVDUs achieved significantly higher rates of overall SVR (70.75 vs 51.04, p<0.0009) and in genotypes 1 and 4 (65.08% vs. 48.73%, p=0.0294) versus non-IVDUs. Treatment discontinuation rates due to side-effects were not significantly different in IVDUs and non IVDUs (2.83% vs. 7.11%, p=0.1390). IVDU group had higher rate of lost to follow up (13.21% vs. 4.60%, p=0.0071). There were no statistical differences in SVR rate between IVDUs with, or without substitution therapy (55.55 vs. 74.62%, p=0.0866). Independent predictors of SVR were age < 40 years and genotypes 2 and 3. Type of PEG-IFN-α was not associated with SVR. Treatment of CHC in IVDUs should strongly be encouraged as they have positive predictors for achieving SVR such as younger age, shorter duration of infection, consequently favorable histological stage of the disease, and good adherence to treatment. There is no difference in safety and tolerability profile of treatment in IVDUs compared to patients with no history of drug abuse.
Projekt / tema: 108-0532264-0048, 143-0000000-0117
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti,Javno zdravstvo i zdravstvena zaštita,Psihologija
URL Internet adrese:
Broj citata:
DOI: 10.5812/kowsar.1735143X.779
URL cjelovitog teksta:
Google Scholar: Intravenous Drug Users Can Achieve a High Sustained Virological Response Rate : Experience From Croatian Reference Center for Viral Hepatitis
Upisao u CROSBI: (, 18. Stu. 2011. u 17:18 sati

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