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Pregled bibliografske jedinice broj: 547574

Časopis

Autori: Pašalić, Daria; Pauković, Paulina; Cvijetić, Selma; Pizent, Alica; Jurasović, Jasna; Milković-Kraus, Sanja; Dodig, Slavica; Muck- Šeler, Dorotea; Mustapić, Maja; Pivac, Nela; Feher-Turković, Lana; Pavlović, Mladen
Naslov: Prostate cancer in elderly Croatian men: 5-HT genetic polymorphisms and the influence of androgen deprivation therapy on osteopenia-a pilot study
( Prostate cancer in elderly Croatian men: 5-HT genetic polymorphisms and the influence of androgen deprivation therapy on osteopenia-a pilot study )
Izvornik: Genetic Testing and Molecular Biomarkers (1945-0265) 16 (2012), 6; 598-604
Vrsta rada: članak
Ključne riječi: prostate cancer; antiandrogen therapy; osteopenia; genetic polymorphisms; serotonine receptors; aged general population
( prostate cancer; antiandrogen therapy; osteopenia; genetic polymorphisms; serotonine receptors; aged general population )
Sažetak:
The aim of this study was to determine the relationship between BMI, biochemical parameters, and 5-HT genetic polymorphisms and prostate dysfunction in elderly general population. 117 elderly men subjects (60 men without symptoms of prostate hyperplasia, 42 men with untreated benign prostatic hyperplasia (BPH), and 15 men with prostate cancer (PCa) treated with finasteride or flutamide were included. Multiple comparisons showed significant difference in age, T-score, concentration of phosphorus, calcium, CRP, and PSA between the groups. T-score was the lowest and phosphorus concentration was the highest in the PCa group. Highest PSA, proteins, calcium, and Hekal’s formula score were found in the BPH group. Patients with PCa were more frequent GG+GA carriers of 5-HT1B 1997A/G gene polymorphism (p=0.035). Univariate regression analysis showed association of PCa-treated subjets with age (p=0.010) and 5-HT1B genetic polymorphism (p=0.018). Antiandrogen therapy affects T-score (p=0.017), serum phosphorus (p=0.008), glucose (p=0.036) and total proteins (p=0.050). Multivariate-stepwise logistic regression analysis showed the significant association of treated PCa with age (p=0.028) and inorganic phosphorus (p=0.005), and a marginal association with ultrasonographic T-score (p=0.052). Antiandrogen therapy might induce bone mineral loss in elderly PCa patients. Preliminary data imply that the genetic variants of 5-HT1B receptor might be associated with PCa.
Projekt / tema: 022-0222411-2409, 022-0222411-2407, 022-0222411-2408, 108-1080316-0298, 098-0982522-2455, 098-0982522-2457, 022-0222411-2409.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti,Javno zdravstvo i zdravstvena zaštita
URL Internet adrese: http://online.liebertpub.com/doi/pdf/10.1089/gtmb.2011.0279
http://online.liebertpub.com/doi/abs/10.1089/gtmb.2011.0279
Broj citata:
Altmetric:
DOI: 10.1089/gtmb.2011.0279
URL cjelovitog teksta:
Google Scholar: Prostate cancer in elderly Croatian men: 5-HT genetic polymorphisms and the influence of androgen deprivation therapy on osteopenia-a pilot study
Upisao u CROSBI: dpasalic@mef.hr (dpasalic@mef.hr), 21. Stu. 2011. u 11:23 sati



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