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Pregled bibliografske jedinice broj: 548160

Časopis

Autori: Obad, Ante; Marinović, Jasna; Ljubković, Marko; Brešković, Toni; Modun, Darko; Boban, Mladen; Dujić, Željko
Naslov: Successive deep dives impair endothelial function and enhance oxidative stress in man
( Successive deep dives impair endothelial function and enhance oxidative stress in man )
Izvornik: Clinical physiology and functional imaging (1475-0961) 30 (2010), 6; 432-438
Vrsta rada: članak
Ključne riječi: endothelium; flow-mediated dilation; oxidative damage; self contained underwater breathing apparatus; trimix
( endothelium; flow-mediated dilation; oxidative damage; self contained underwater breathing apparatus; trimix )
Sažetak:
The aim of this study was to assess the effects of successive deep dives on endothelial function of large conduit arteries and plasma pro-oxidant and antioxidant activity. Seven experienced divers performed six dives in six consecutive days using a compressed mixture of oxygen, helium and nitrogen (trimix) with diving depths ranging from 55 to 80 m. Before and after first, third and sixth dive, venous gas emboli formation and brachial artery function (flow-mediated dilation, FMD) was assessed by ultrasound. In addition, plasma antioxidant capacity (AOC) was measured by ferric reducing antioxidant power, and the level of oxidative stress was assessed by thiobarbituric acid-reactive substances (TBARS) method. Although the FMD was reduced to a similar extent after each dive, the comparison of predive FMD showed a reduction from 8·6% recorded before the first dive to 6·3% before the third (P = 0·03) and 5·7% before the sixth dive (P = 0·003). A gradual shift in baseline was also detected with TBARS assay, with malondialdehyde values increasing from 0·10 ± 0·02 μmol l−1 before the first dive to 0·16 ± 0·03 before the sixth (P = 0·005). Predive plasma AOC values also showed a decreasing trend from 0·67 ± 0·20 mmol l−1 trolox equivalents (first day) to 0·56 ± 0·12 (sixth day), although statistical significance was not reached (P = 0·08). This is the first documentation of acute endothelial dysfunction in the large conduit arteries occurring after successive deep trimix dives. Both endothelial function and plasma pro-oxidant and antioxidant activity did not return to baseline during the course of repetitive dives, indicating possible cumulative and longer lasting detrimental effects.
Projekt / tema: 216-2160133-0130
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: http://onlinelibrary.wiley.com/doi/10.1111/j.1475-097X.2010.00962.x/abstract
Broj citata:
Altmetric:
DOI: 10.1111/j.1475-097X.2010.00962.x
URL cjelovitog teksta:
Google Scholar: Successive deep dives impair endothelial function and enhance oxidative stress in man
Upisao u CROSBI: vivancev@mefst.hr (vivancev@mefst.hr), 21. Stu. 2011. u 13:53 sati



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