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Pregled bibliografske jedinice broj: 55085

Časopis

Autori: Sikirić, Predrag; Seiwerth, Sven; Grabarević, Željko; Ručman, Rudolf; Petek, Marijan; Jagić, Vjekoslav; Turković, Branko; Rotkvić, Ivo; Miše, Stjepan; Zoričić, Ivan; Jurina, Ljubica; Konjevoda, Paško; Hanževački, Miro; Ljubanović, Danica; Šeparović, Jadranka; Gjurašin, Miro; Bratulić, Mirna; Artuković, Branka; Jelovac, Nikola; Buljat, Gojko
Naslov: Salutary and prophylactic effect of pentadecapeptide BPC 157 on acute pancreatitis and concomitant gastroduodenal lesions in rats.
( Salutary and prophylactic effect of pentadecapeptide BPC 157 on acute pancreatitis and concomitant gastroduodenal lesions in rats. )
Izvornik: Digestive Diseases and Sciences (0163-2116) 41 (1996), 7; 1518-1526
Vrsta rada: članak
Ključne riječi: pentadekapeptide BPC 157; acute pancreatitis; gastroduodenal lesions
( pentadekapeptide BPC 157; acute pancreatitis; gastroduodenal lesions )
Sažetak:
The superior effectiveness of a new pentadecapeptide, BPC 157, on gastrointestinal and liver lesions, in conjunction with an antiinflammatory and analgetic activity was recently noted. In the present study, BPC 157 was tested as either a protective or healing agent in bile duct ligation-induced acute pancreatitis in rats. In addition, the positive influence of BPC 157 on concomitantly developed gastric and duodenal lesions was simultaneously investigated. BPC 157 (10 microg, 10 ng/kg body wt, intraperitoneally or intragastrically) was given prophylactically 1 hr before ligation, whereas the therapy was given once daily beginning with the 24 hr following ligation (last application 24 hr before killing). The effect was investigated at daily intervals until the end of the fifth day after ligation. In the pretreatment regimen, a strong pancreas protection was obtained. When applied in the condition of already established severe acute pancreatitis, an obvious salutory effect was consistently noted. Assessing the appearance of the necrosis, edema, neutrophils, and mononuclears, consistently less necrosis, edema, and neutrophils, but more mononuclears, were found in BPC-treated rats. Likewise, in studies of the serum amylase values, relative to control data, a markedly lower rise (BPC pretreatment regimen) as well as a worsening of the already raised values (BPC therapy regimen) was noted. Along with its beneficial effect on pancreatitis, a positive influence of BPC 157 on the gastric and duodenal lesion course in bile duct-ligated rats was noted in both the pre- and posttreatment regimen. Taken together, in further studies of acute pancreatitis therapy, BPC could be an interesting and useful agent with an additional positive impact on concomitant gastroduodenal pathology.
Projekt / tema: 053019, 0108196
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL cjelovitog teksta:
Google Scholar: Salutary and prophylactic effect of pentadecapeptide BPC 157 on acute pancreatitis and concomitant gastroduodenal lesions in rats.



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