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Pregled bibliografske jedinice broj: 551733

Zbornik radova

Autori: Škorjanec, Sandra; Dolovski, Zdravko; Sever, Marko; Kliček, Robert; Drmić, Domagoj; Radić, Božo; Brčić, Luka; Kolenc, Danijela; Boban Blagaić, Alenka; Jelaska, Aida; Gjurašin, Miroslav; Turković, Branko; Seiwerth, Sven; Ručman, Rudolf; Sikirić, Predrag
Naslov: Stable gastric pentadecapeptide BPC 157 may heal duodenocutaneous fistulas in rats
( Stable gastric pentadecapeptide BPC 157 may heal duodenocutaneous fistulas in rats )
Izvornik: Abstracts of the ….. ; u: Gastroenterology 140 (2011) (5/S1)
ISSN: 0016-5085
Skup:
Mjesto i datum: ,
Ključne riječi: stable gastric pentadecapeptide BPC 157; duodenocutaneous fistulas; rats
( stable gastric pentadecapeptide BPC 157; duodenocutaneous fistulas; rats )
Sažetak:
We investigate the healing of duodenocutaneous fistulas in rats and stable gastric pentadecapeptide BPC 157. We recently focused on unhealed gastrocutaneous fistulas (2-mm-diameter stomach defect, 3-mm-diameter skin defect) to resolve whether standard drugs that promote healing of gastric ulcers may simultaneously have the same effect on cutaneous wounds, corticosteroid aggravation, and to demonstrate why peptides such as BPC 157 exhibit a greater healing effect. Therefore, with the fistulas therapy, we challenge the wound/growth factors theory of the analogous nonhealing of wounds and persistent gastric ulcers. We suggested that the healing rate of gastrocutaneous fistula in rats validates macro/microscopically and biomechanically a direct skin wound/stomach ulcer relation, and identifies a potential therapy consisting of: (i) stable gastric pentadecapeptide BPC 157 [in drinking water (10 lg/kg) (12 ml/rat/day) or intraperitoneally (10 lg/kg, 10 ng/kg, 10 pg/kg)], (ii) atropine (10 mg/kg), ranitidine (50 mg/kg), and omeprazole (50 mg/kg), (iii) 6-alpha-methylprednisolone (1 mg/kg) [intraperitoneally, once daily, first application at 30 min following surgery ; last 24 h before sacrifice (at postoperative days 1, 2, 3, 7, 14, and 21)]. We clearly demonstrated a greater anti-ulcer potential and efficiency in wound healing compared with standard agents, favoring BPC 157, efficient in inflammatory bowel disease (PL-14736, Pliva), given in drinking water or intraperitoneally. Even after 6-alpha-methylprednisolone aggravation, BPC 157 promptly improves both skin and stomach mucosa healing, and closure of fistulas, with no leakage after up to 20 ml water intragastrically. Standard anti-ulcer agents, after a delay, improve firstly skin healing and then stomach mucosal healing, but not fistula leaking and bursting strength (except for atropine). Now, we demonstrated that unhealed duodenocutaneous fistula while with more severe course, may have the most rapid healing with pentadecapeptide BPC 157 regimens, given intrapetitoneally or in drinking water. Conclusion. BPC 157 may resolve analogous nonhealing of wounds and persistent gastric ulcers as well as duodenal ulcers better than standard agents, and thereby, BPC 157 may be successfully applied in further therapy.
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Nema recenziju
Projekt / tema: 108-1083570-3643, 108-1083570-3635
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Upisao u CROSBI: idrmic@mef.hr (idrmic@mef.hr), 23. Stu. 2011. u 03:07 sati



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