engleski

Relationship between C-reactive proteine and cerebrovascular stenosis

Objective: C-reactive protein as a non-specific biomarker of inflammation has been demonstrated to actively contribute to all stages of atherogenesis. The aim of this study was to evaluate whether there is an association between CRP and stenosis of cerebral arteries. Patients and methods: Lipid profile and CRP levels were measured in serum of 119 patients mean age of 66 years (range 40-83 years) with stenosis of extracranial cerebral arteries of more than 50%, established angiographically and compared with age- and sex-matched controls mean age of 61 years (range 44-82 years), with normal cerebral arteries on ultrasound examination. CRP concentrations were determined by automated high-sensitivity latex- enhanced immuno-turbidimetric assay (Olympus). The day-to-day imprecision (CV) for the hs-CRP assay at concentrations of 1.30 mg/L and 16.0 mg/L was 4.1% and 2.7% respectively. Results: Univariate statistical evaluation showed significantly higher CRP levels in the group of patients with stenosis than in the controls (median values 5.0 mg/L versus 2.6 mg/L, p<0.05). The lipid profile showed significantly increased values for triglycerides and LDL-cholesterol and decreased concentrations of HDL-cholesterol in the group of patients with stenosis versus control group (p<0.05). The positive relationship between CRP and index of atherosclerosis was observed in the group of cerebrovascular stenosis (r=0.21 ; p<0.05). Conclusions: CRP measured on automated analysers using high sensitivity assay may be a simple and useful additional biomarker of subclinical inflammatory states in patients with stenosis of cerebral arteries.

C-reactive protein; stenosis of cerebral arteries; biomarker of inflammation

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