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Pregled bibliografske jedinice broj: 561351

Časopis

Autori: Akcay, A., ...; Pačić, Arijana; Galešić Ljubanović, Danica; ...; Edelstein C.L.
Naslov: IL-33 exacerbates acute kidney injury
( IL-33 exacerbates acute kidney injury )
Izvornik: Journal of the American Society of Nephrology (1046-6673) 22 (2011), 11; 2057-2067
Vrsta rada: članak
Ključne riječi: acute kidney injury; IL-33; cisplatin
( acute kidney injury; IL-33; cisplatin )
Sažetak:
Inflammation contributes to the pathogenesis of acute kidney injury (AKI). IL-33 is a proinflammatory cytokine, but its role in AKI is unknown. Here we observed increased protein expression of full-length IL-33 in the kidney following induction of AKI with cisplatin. To determine whether IL-33 promotes injury, we administered soluble ST2 (sST2), a fusion protein that neutralizes IL-33 activity by acting as a decoy receptor. Compared with cisplatin-induced AKI in untreated mice, mice treated with sST2 had fewer CD4 T cells infiltrate the kidney, lower serum creatinine, and reduced acute tubular necrosis (ATN) and apoptosis. In contrast, administration of recombinant IL-33 (rIL-33) exacerbated cisplatin-induced AKI, measured by an increase in CD4 T cell infiltration, serum creatinine, ATN, and apoptosis ; this did not occur in CD4-deficient mice, suggesting that CD4 T cells mediate the injurious effect of IL-33. Wildtype mice that received cisplatin and rIL-33 also had higher levels of the proinflammatory chemokine CXCL1, which CD T cells produce, in the kidney compared with CD4-deficient mice. Mice deficient in the CXCL1 receptor also had lower serum creatinine, ATN, and apoptosis than wildtype mice following cisplatin-induced AKI. Taken together, IL-33 promotes AKI through CD4 T cell-mediated production of CXCL1. These data suggest that inhibiting IL-33 or CXCL1 may have therapeutic potential in AKI.
Projekt / tema: 198-0000000-3355
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://jasn.asnjournals.org/content/22/11/2057.abstract
http://jasn.asnjournals.org/content/22/11/2057.full.pdf+html
Broj citata:
Altmetric:
DOI: 10.1681/ASN.2010091011
URL cjelovitog teksta:
Google Scholar: IL-33 exacerbates acute kidney injury
Upisao u CROSBI: dljubanovic@mef.hr (dljubanovic@mef.hr), 29. Stu. 2011. u 01:59 sati



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