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Pregled bibliografske jedinice broj: 561364

Časopis

Autori: Renner, B.; ...; Ljubanović, D.; ...; Thurman, J.M.
Naslov: B cell subsets contribute to renal injury and renal protection after ischemia/reperfusion
( B cell subsets contribute to renal injury and renal protection after ischemia/reperfusion )
Izvornik: Journal of immunology (0022-1767) 185 (2010), 7; 4393-4400
Vrsta rada: članak
Ključne riječi: ischemia/reperfusion; kidney; complement activation; natural Ab
( ischemia/reperfusion; kidney; complement activation; natural Ab )
Sažetak:
Ischemia/reperfusion (I/R) triggers a robust inflammatory response within the kidney. Numerous components of the immune system contribute to the resultant renal injury, including the complement system. We sought to identify whether natural Abs bind to the postischemic kidney and contribute to complement activation after I/R.We depleted peritoneal B cells in mice by hypotonic shock. Depletion of the peritoneal B cells prevented the deposition of IgM within the glomeruli after renal I/R and attenuated renal injury after I/R.We found that glomerular IgM activates the classical pathway of complement, but it does not cause substantial deposition of C3 within the kidney. Furthermore, mice deficient in classical pathway proteins were not protected from injury, indicating that glomerular IgM does not cause injury through activation of the classical pathway. We also subjected mice deficient in all mature B cells (mMT mice) to renal I/R and found that they sustained worse renal injury than wild-type controls. Serum IL-10 levels were lower in the mMT mice. Taken together, these results indicate that natural Ab produced by peritoneal B cells binds within the glomerulus after renal I/R and contributes to functional renal injury. However, nonperitoneal B cells attenuate renal injury after I/R, possibly through the production of IL-10.
Projekt / tema: 198-0000000-3355
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://jimmunol.org/content/185/7/4393.abstract
http://jimmunol.org/content/185/7/4393.full.pdf+html
Broj citata:
Altmetric:
DOI: 10.4049/jimmunol.0903239
URL cjelovitog teksta:
Google Scholar: B cell subsets contribute to renal injury and renal protection after ischemia/reperfusion
Upisao u CROSBI: dljubanovic@mef.hr (dljubanovic@mef.hr), 29. Stu. 2011. u 02:37 sati



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