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Pregled bibliografske jedinice broj: 561375

Časopis

Autori: Renner, B.; ...; Ljubanović, Danica; ...; Thurman, J.M.
Naslov: Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury
( Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury )
Izvornik: Kidney international (0085-2538) 80 (2011), 2; 165-173
Vrsta rada: članak
Ključne riječi: kidney; ishemic injury; complement activation; factor H
( kidney; ishemic injury; complement activation; factor H )
Sažetak:
Factor H is a regulator of the alternative pathway of complement, and genetic studies have shown that patients with mutations in factor H are at increased risk for several types of renal disease. Pathogenic activation of the alternative pathway in acquired diseases, such as ischemic acute kidney injury, suggests that native factor H has a limited capacity to control the alternative pathway in the kidney. Here we found that an absolute deficiency of factor H produced by gene deletion prevented complement activation on tubulointerstitial cells after ischemia/reperfusion (I/R) injury, likely because alternative pathway proteins were consumed in the fluid phase. In contrast, when fluid-phase regulation by factor H was maintained while the interaction of factor H with cell surfaces was blocked by a recombinant inhibitor protein, complement activation after renal I/R increased. Finally, a recombinant form of factor H, specifically targeted to sites of C3 deposition, reduced complement activation in the tubulointerstitium after ischemic injury. Thus, although factor H does not fully prevent activation of the alternative pathway of complement on ischemic tubules, its interaction with the tubule epithelial cell surface is critical for limiting complement activation and attenuating renal injury after ischemia.
Projekt / tema: 198-0000000-3355
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.nature.com/ki/journal/v80/n2/abs/ki2011115a.html
Broj citata:
Altmetric:
DOI: 10.1038/ki.2011.115
URL cjelovitog teksta:
Google Scholar: Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury
Upisao u CROSBI: dljubanovic@mef.hr (dljubanovic@mef.hr), 29. Stu. 2011. u 03:18 sati



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