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Autori: Čikeš Čulić, Vedrana; Glavaš, Duška; Markotić, Anita; Valić, Zoran; Kovačić, Nataša; Palada, Ivan; Martinić, Roko; Brešković, Toni; Baković, Darija; Brubakk, Alf O; Dujić, Željko
Naslov: Expression of endothelial selectin ligands on human leukocytes following dive. FEBS J 2009 ; 276: 193
Izvornik: FEBS JWiley , 2009. 276:193-193.
ISSN: 1742-464X
Skup: 34th FEBS Congress, Life's Molecular Interactions
Mjesto i datum: Prag, Čehoslovačka, 4-9.07.2009.
Ključne riječi: endothelial function; monocyte; sialyl-Lewis x; ultrasound
Sažetak:
Lewis x (CD15) and sialyl-Lewis x (CD15s) are granulocyte and monocyte carbohydrate antigens recognized as ligands by endothelial selectins. We assumed that CD15 and CD15s could be sensitive markers for impaired vasodilatation following diving. Using flow-cytometry, we determined CD15+ and CD15s+ peripheral blood mononuclear cells of eight divers, 30 min before and 50 min after a single dive to 54 m for 20 min bottom time. The number of gas bubbles in the right heart was monitored by ultrasound. Gas bubbles were seen in all 8 divers, with the average number of bubbles/cm2 1.9± 1.9. Proportion of CD15+ monocytes increased two fold after dive as well as subpopulation of monocytes highly expressing CD15s, the absolute number of monocytes was slightly but no significantly increased after dive, whereas absolute number of granulocytes was markedly elevated (up to 61%) after dive. There was not correlation between CD15+ monocytes expression and bubbles production (p = , 555 ; r = -, 2471) as well as between monocytes highly expressing CD15s and bubbles production (p = , 288 ; r = , 42983. This suggests that biochemical changes induced by diving primary activate existing monocytes rather than increase the number of monocytes at a time of acute arterial endothelial dysfunction.
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bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 216-2160133-0066, 216-2160133-0130
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Farmacija
Upisao u CROSBI: amarkoti@mefst.hr (amarkoti@mefst.hr), 20. Pro. 2011. u 12:37 sati



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