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Pregled bibliografske jedinice broj: 56977

Časopis

Autori: Telišman, Spomenka; Jurasović, Jasna; Pizent, Alica; Cvitković, Petar
Naslov: Blood pressure in relation to biomarkers of lead, cadmium, copper, zinc, and selenium in men without occupational exposure to metals
( Blood pressure in relation to biomarkers of lead, cadmium, copper, zinc, and selenium in men without occupational exposure to metals )
Izvornik: Environmental Research (0013-9351) 87 (2001), 2; 57-68
Vrsta rada: članak
Ključne riječi: Lead; erythrocyte protoporphyrin; age; alcohol; smoking; cadmium; human blood pressure
( Lead; erythrocyte protoporphyrin; age; alcohol; smoking; cadmium; human blood pressure )
Sažetak:
The interrelationship of blood lead (BPb), activity of delta-aminolevulinic acid dehydratase (ALAD), erythrocyte protoporphyrin (EP), blood cadmium (BCd), serum copper (SCu), serum zinc (SZn), serum selenium (SSe), hematocrit (Hct), body mass index (BMI), age, smoking habits, and alcohol consumption to blood pressure was examined in 154 Croatian male subjects 19-53 years of age. None of the subjects had been occupationally exposed to metals, or used any medication that could influence blood pressure or metal metabolism. The median and range values were: BPb, 57 (25-254) ľg/L; ALAD, 51.9 (22.8-96.4) European units; EP, 0.68 (0.38-1.68) ľmol/L erythrocytes; BCd, 0.83 (0.21-11.93) ľg/L; SCu, 1113 (763-1662) ľg/L; SZn, 961 (734-1213) ľg/L; SSe, 73.6 (44.2-106.9) ľg/L; systolic blood pressure, 131 (105-165) mm Hg; and diastolic blood pressure, 94 (71-112) mm Hg. Systolic and diastolic blood pressure significantly correlated with an increase in BMI (p<0.0005 and p<0.0001, respectively), EP (p<0.0002 and p<0.002, respectively), and BPb (p<0.005 and p<0.01, respectively). After adjusting for potential confounding variables by multiple regression, an increase in systolic blood pressure was significantly predictive by BMI (p<0.0005) and log BPb (p<0.02) and inversly by logBPb*SSe interaction term (p<0.007), or alternatively by EP (P<0.0001), BMI (p<0.001), alcohol (p<0.02), and Hct (p<0.05). An increase in diastolic blood pressure was significantly predictive by BMI (p<10^-5), log BPb (p<0.04), and alcohol (p=0.05) and inversely by logBPb*SSe interaction term (p<0.0007), or alternatively by BMI (p<0.0001), EP (p<0.002), alcohol (p<0.004), and Hct (p<0.04) and inversely by smoking (p<0.04). With respect to the EP range in the study population, an increase of 27 mm Hg in systolic and 14 mm Hg in diastolic blood pressure was found. The study results indicate a significant Pb-related increase in blood pressure, particularly within the low-level Pb exposure range (BPb of 25-75 ľg/L, and/or EP of 0.4-1.0 ľmol/L erythrocytes).
Projekt / tema: 00220304
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Javno zdravstvo i zdravstvena zaštita
URL cjelovitog teksta:
Google Scholar: Blood pressure in relation to biomarkers of lead, cadmium, copper, zinc, and selenium in men without occupational exposure to metals



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