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Pregled bibliografske jedinice broj: 571635

Časopis

Autori: Bilić, Marija; Munjas-Samarin, Radenka; Galešić Ljubanović, Danica; Horvatić, Ivica; Galešić, Krešimir
Naslov: Effects of Ramipril and Valsartan on Proteinuria and Renal Function in Patients with Nondiabetic Proteinuria
( Effects of Ramipril and Valsartan on Proteinuria and Renal Function in Patients with Nondiabetic Proteinuria )
Izvornik: Collegium antropologicum (0350-6134) 35 (2011), 4; 1061-1066
Vrsta rada: članak
Ključne riječi: angiotensin-converting enzyme inhibitors; angiotensin II receptor blockers; proteinuria; renoprotection
( angiotensin-converting enzyme inhibitors; angiotensin II receptor blockers; proteinuria; renoprotection )
Sažetak:
The renin-angiotensin system is involved in the progression of chronic renal disease of both diabetic and nondiabetic origin. The angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers have been demonstrated to reduce urinary protein excretion and attenuate the development of renal injury. This prospective, randomized, 12-month study assessed the effects of ramipril (N=23) vs. valsartan (N=22) vs. combination of ramipril and valsartan (N=26) on proteinuria, renal function and metabolic profile in 71 patients with nondiabetic proteinuria with normal or slightly impaired renal function. Monotherapy with ramipril or valsartan and combination of these two drugs significantly reduced proteinuria, serum creatinine, cholesterol and triglycerides as well as systolic and diastolic arterial blood pressure. There was no significant difference among three study groups according to reduction of arterial blood pressure, serum cholesterol and triglycerides. At one year, a significant reduction in serum creatinine was recorded in all three study groups, whereas at 3 and 6 months a statistically significant reduction in serum creatinine was only observed in patients on combination therapy. In addition, at 3 months the reduction of proteinuria was significantly greater in patients on combination therapy than in those on either monotherapy. These results indicated the combination therapy with angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers to be more efficacious than either monotherapy in reducing proteinuria and serum creatinine level in the first 3 (proteinuria and serum creatinine) or 6 (serum creatinine) months of treatment.
Projekt / tema: 198-0000000-0179
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Social Science Citation Index (SSCI) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
URL Internet adrese: http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=112330
URL cjelovitog teksta:
Google Scholar: Effects of Ramipril and Valsartan on Proteinuria and Renal Function in Patients with Nondiabetic Proteinuria
Upisao u CROSBI: mtisljar@kbd.hr (mtisljar@kbd.hr), 20. Vel. 2012. u 17:09 sati



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