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Pregled bibliografske jedinice broj: 571698

Zbornik radova

Autori: Basarić, Nikola; Veljković, Jelena; Mlinarić-Majerski, Kata; Uzelac, Lidija; Kralj, Marijeta; Wan, Peter
Naslov: Photochemical formation and investigation of antiproliferative effect of adamantylnaphthalene quinone methides
Izvornik: Central European Conference on Photochemistry/CECP 2012/Bad Hofgastein, Austria
Skup: Central European Conference on Photochemistry/CECP 2012/Bad Hofgastein, Austria
Mjesto i datum: Bad Hofgastein, Austrija, 05-09.02.2012.
Ključne riječi: antiproliferative effect; hydroxyadamantyl; aminoadamantyl; quinone methides;
Sažetak:
Recently we have become interested in photochemical formation of sterically congested quinone methides (QM) [1]. We have found out that introduction of a bulky adamantyl substituent at the methylene position of QMs hinders attack of nucleophiles resulting in longer-lived species and selectivity towards N-nucleophiles. In continuation of that research we studied photochemistry of QMs formed from adamantyl derivatives of phenylphenols and investigated antiproliferative effect of the QMs on three human cancer cell lines [2]. Prompted by the discovery of lead compounds with antiproliferative effect in phenylphenol series and reports on photochemical formation of naphthalene derivatives of QMs [3] we introduced hydroxyadamantyl or aminoadamantyl moiety into different positions of naphthols (1-5). Photochemistry of 1-5 was studied by preparative irradiations in the presence of nucleophiles, fluorescence, and laser flash photolysis. Antiproliferative effect of compounds was investigated with and without irradiations in vitro on three human cancer cell lines HCT 116 (colon), MCF-7 (breast), and H 460 (lung).
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 098-0982933-2911, 02.05/25
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Kemija
Upisao u CROSBI: eluksa@irb.hr (eluksa@irb.hr), 21. Vel. 2012. u 10:56 sati



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