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Pregled bibliografske jedinice broj: 574043

Časopis

Autori: Mršić, Gordan; Gršković, Branka; Vrdoljak, Andro; Popović, Maja; Valpotić, Ivica; Anđelinović, Šimun; Stenzl, Vlastimil; Ehler, Edvard; Urban, Ludvik; Lacković, Gordana; Underhill, Peter; Primorac, Dragan
Naslov: Croatian national reference Y-STR haplotype database
Izvornik: Molecular biology reports (0301-4851) 39 (2012), 7; 7727-7741
Vrsta rada: članak
Ključne riječi: Y chromosome; Short tandem repeat; Population genetics; Haplotypes; Haplogroups; Croatian population
Sažetak:
A reference Y-chromosome short tandem repeat (STR) haplotype database is needed for Y-STR match interpretation as well as for national and regional characterization of populations. The aim of this study was to create a comprehensive Y-STR haplotype database of the Croatian contemporary population and to analyze substructure between the five Croatian regions. We carried out a statistical analysis of the data from previously performed genetic analyses collected during routine forensic work by the Forensic Science Centre “Ivan Vučetić”. A total of 1100 unrelated men from eastern, western, northern, southern and central Croatia were selected for the purpose of this study. Y-chromosomal STRs were typed using the AmpFISTR Yfiler PCR amplification kit. Analysis of molecular variance calculated with the Y chromosome haplotype reference database online analysis tool included 16 population samples with 20247 haplotypes. A total of 947 haplotypes were recorded, 848 of which were unique (89.5%). Haplotype diversity was 0.998, with the most frequent haplotype found in 9 of 1100 men (0.82%). Locus diversity varied from 0.266 for DYS392 to 0.868 for DYS385. Discrimination capacity was 86.1%. Our results suggested high level of similarity among regional subpopulations within Croatia, except for mildly different southern Croatia. Relative resemblance was found with Bosnia and Herzegovina and Serbia. Whit Atheys ́ Haplogroup Predictor was used to estimate the frequencies of Y-chromosome haplogroups. I2a, R1a, E1b1b and R1b haplogroups were most common in Croatian regions. These results are important in forensics and contribute to the population genetics and genetic background of the contemporary Croatian population.
Projekt / tema: 053-0532265-2255
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Biologija,Temeljne medicinske znanosti
URL Internet adrese: http://www.springerlink.com/openurl.asp?genre=article&id=doi:10.1007/s11033-012-1610-3
Broj citata:
Altmetric:
DOI: 10.1007/s11033-012-1610-3
URL cjelovitog teksta:
Google Scholar: Croatian national reference Y-STR haplotype database
Upisao u CROSBI: gmrsic@public.hr (gmrsic@public.hr), 14. Ožu. 2012. u 12:06 sati



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