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Pregled bibliografske jedinice broj: 576347

Časopis

Autori: Štimac, Adela; Šegota, Suzana; Dutour Sikirić, Maja; Ribić, Rosana; Frkanec, Leo; Svetličić, Vesna; Tomić, Srđanka; Vranešić, Branka; Frkanec, Ruža
Naslov: Surface Modified Liposomes by Mannosylated Conjugates Anchored via the Adamantyl Moiety in the Lipid Bilayer
( Surface Modified Liposomes by Mannosylated Conjugates Anchored via the Adamantyl Moiety in the Lipid Bilayer )
Izvornik: Biochimica et biophysica acta. Biomembranes (0005-2736) 1818 (2012), 9; 2252-2259
Vrsta rada: članak
Ključne riječi: adamantane; mannose; liposome targeting; AFM; DLS
( adamantane; mannose; liposome targeting; AFM; DLS )
Sažetak:
The aim of the present study was to encapsulate mannosylated 1-aminoadamantane and mannosylated adamantyltripeptides, namely [(2R)-N-(adamant-1-yl)-3-(a, b-D-mannopyranosyloxy)-2-methylpropanamide and (2R)-N-[3-(α-D-mannopyranosyloxy)-2-methylpropanoyl]-D, L-(adamant-2-yl)glycyl-L-alanyl-D-isoglutamine] in liposomes. The characterization of liposomes, size and surface morphology was performed using dynamic light scattering (DLS) and atomic force microscopy (AFM). The results have revealed that the encapsulation of examined compounds changes the size and surface of liposomes. After the Concanavalin A (ConA) was added to the liposome preparation, increase in liposome size and their aggregation has been observed. The enlargement of liposomes was ascribed to the specific binding of the ConA to the mannose present on the surface of the prepared liposomes. Thus, it has been shown that the adamantyl moiety from mannosylated 1-aminoadamantane and mannosylated adamantyltripeptides can be used as an anchor in the lipid bilayer for carbohydrate moiety exposed on the liposome surface.
Projekt / tema: 021-0212432-2431, 119-1191344-3121, 098-0982934-2744, 098-0982904-2912
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti,Biotehnologija
URL Internet adrese: http://dx.doi.org/10.1016/j.bbamem.2012.04.002
http://ac.els-cdn.com/S0005273612001241/1-s2.0-S0005273612001241-main.pdf?_tid=c97af9aa-06e6-11e2-baf9-00000aacb362&acdnat=1348560086_48ace6bf45cee85d6534a092e1d02245
http://www.sciencedirect.com/science/article/pii/S0005273612001241
Broj citata:
Altmetric:
DOI: 10.1016/j.bbamem.2012.04.002
URL cjelovitog teksta: http://dx.doi.org/10.1016/j.bbamem.2012.04.002
Google Scholar: Surface Modified Liposomes by Mannosylated Conjugates Anchored via the Adamantyl Moiety in the Lipid Bilayer
Upisao u CROSBI: rfrkanec@imz.hr (rfrkanec@imz.hr), 10. Tra. 2012. u 10:46 sati



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