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Pregled bibliografske jedinice broj: 58272

Časopis

Autori: Raić-Malić, Silvana; Grdiša, Mira; Pavelić, Krešimir; Mintas, Mladen
Naslov: Synthesis and biological evaluation of the novel purine and pyrimidine nucleoside analogues containing 2,3-epoxypropyl, 3-amino-2-hydroxypropyl or 2,3-epoxypropyl ether moieties
Izvornik: European Journal of Medicinal Chemistry (0223-5234) 34 (1999); 405-413
Vrsta rada: članak
Ključne riječi: purine and pyrimidine nucleoside analogues; 1H and 13C NMR; 2D homo- and hetero-nuclear correlation spectroscopy; antitumour activity; antiviral activity
Sažetak:
The novel purine and pyrimidine nucleoside analogues possessing a 2,3-epoxypropyl (2a-2c and 8a-8c), 2,3-epoxypropyl ether (3), or 3-amino-2-hidroxypropyl (4a-6c and 9a-9c) moiety bonded at either N-9 of the C-6 substituted purine ring or N-1 and N-3 of the pyrimidine ring, were prepared and evaluated on their antitumour and antiviral activities. Compounds 3, 6b, 8b and 8c showed marked inhibition of growth of human tumour cell lines (MiaPaCa2 and Raji), whilst the inhibitory effect of 6b was greated against Raji cell than to the MiaPaCa2 ones. No specific activity of compounds 2a-3, 4a-6c and 9a-9c against HSV and VZV was detected. The compounds 6b was highly active against the replication of HIV 1 (IIIB), while 2a-2c and 8a-8c were inactive.
Projekt / tema: 00981104, 125003
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija
URL cjelovitog teksta:
Google Scholar: Synthesis and biological evaluation of the novel purine and pyrimidine nucleoside analogues containing 2,3-epoxypropyl, 3-amino-2-hydroxypropyl or 2,3-epoxypropyl ether moieties



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