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Pregled bibliografske jedinice broj: 590714

Časopis

Autori: Jaganjac, Morana; Čačev, Tamara; Čipak, Ana; Kapitanović, Sanja; Gall-Troselj, Koraljka; Žarković, Neven
Naslov: Even stressed cells are individuals: second messengers of free radicals in pathophysiology of cancer
Izvornik: Croatian medical journal (0353-9504) 53 (2012), 4; 304-309
Vrsta rada: članak
Ključne riječi: oxidative stress; personalized medicine
Sažetak:
Pathophysiological processes associated with disturbances in cell and tissue oxidative homeostasis, are associated with self-catalyzed process of lipid peroxidation. The end products of lipid peroxidation are reactive aldehydes such as 4-hydroxy-2-nonenal (HNE), acting as "second messengers of free radicals." Although reactive aldehydes were first recognized only as cytotoxic, new evidence has come to light, related to their cell growth regulatory functions achieved through cell signaling. The variable appearance of HNE in several organs indicates that its mode of action might be related to an individual cell stress adaptation. The underlying mechanism could be that specific mutations and epigenetic changes on one hand interfere with hormesis on the other. The precise role of oxidative stress and lipid peroxidation in these processes still needs more clarification at molecular level. Finally, an individual approach to each patient, based on the individual cell response to stress, opens a new possibility of integrative medicine in cancer treatment and strongly supports modern concepts of personalized medicine.
Projekt / tema: 098-0982464-2511, 098-0982464-2508, 098-0982464-2519
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://fulir.irb.hr/2690/1/Zarkovic_CMJ_53_4_304.pdf
http://www.cmj.hr/2012/53/4/22911521.htm
Broj citata:
Altmetric:
DOI: 10.3325/cmj.2012.53.304
URL cjelovitog teksta:
Google Scholar: Even stressed cells are individuals: second messengers of free radicals in pathophysiology of cancer
Upisao u CROSBI: mzivkovi@irb.hr (mzivkovi@irb.hr), 29. Kol. 2012. u 13:33 sati



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