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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 590806

Časopis

Autori: Babić, Željka; Tariba, Blanka; Kovačić, Jelena; Pizent, Alica; Varnai, Veda Marija; Macan, Jelena
Naslov: Relevance of serum copper elevation induced by oral contraceptives : a meta-analysis
( Relevance of serum copper elevation induced by oral contraceptives : a meta-analysis )
Izvornik: Contraception (0010-7824) 87 (2013), 6; 790-800
Vrsta rada: članak
Ključne riječi: ceruloplasmin; copper; estrogen; oxidative stress; hepatic damage; atherosclerosis
( ceruloplasmin; copper; estrogen; oxidative stress; hepatic damage; atherosclerosis )
Sažetak:
It is well documented that copper (Cu) blood levels are elevated in combination oral contraceptive (COC) users. The aim of this study was to establish the range of Cu increase in OC users compared to nonusers through a systematic literature overview and quantitative data analysis. Twenty-six articles were included in the meta-analysis. The increase in Cu level exponentially decreased in COC users over time, with a rapid decline through the 1960s and 1970s. After controlling for the publication year, use of COC increases the mean serum/plasma Cu level by 0.57 mg/L (95% confidence interval 0.49-0.66 mg/L). COCs commonly raise serum Cu to levels between 1.5 and 2 mg/L, which are above reference levels. Although these levels are not considered toxic, there are suggestions that such Cu increase could be implicated in oxidative pathophysiological processes in the body. Further research on safety of COCs use, including oxidative-stress-related effects, is warranted.
Projekt / tema: 022-0222411-2408, 022-0222411-2410
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti,Javno zdravstvo i zdravstvena zaštita
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S0010782412008955
http://dx.doi.org/10.1016/j.contraception.2012.10.006
Broj citata:
Altmetric:
DOI: 10.1016/j.contraception.2012.10.006
URL cjelovitog teksta:
Google Scholar: Relevance of serum copper elevation induced by oral contraceptives : a meta-analysis
Upisao u CROSBI: jmacan@imi.hr (jmacan@imi.hr), 30. Kol. 2012. u 10:07 sati



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