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Pregled bibliografske jedinice broj: 590982

Zbornik radova

Autori: Gršković, Branka; Mršić, Gordan; Vrdoljak, Andro; Popović, Maja; Valpotić, Ivica; Anđelinović, Šimun; Stenzl, Vlastimil; Ehler, Edvard; Urban, Ludvik; Lacković, Gordana; Underhill, Peter; Primorac, Dragan
Naslov: Haplogroup diversification of contemporary Croatian population
Izvornik: Forensica 2012 - Abstract book and conference program / Drabek, Jiri (ur.). - Brno, Češka : Tribun EU s.r.o. , 2012. 46-47 (ISBN: 978-80-263-0239-1).
Skup: The 3rd International Conference on Forensic Genetics
Mjesto i datum: Lednice, Češka, 21-24.05.2012.
Ključne riječi: Y-chromosome; short tandem repeat; population genetics; haplotypes; haplogroup; Croatian population
Sažetak:
Introduction: Comprehensive Croatian Y-chromosome short tandem repeat (STR) haplotype database on national and regional levels is important to get an insight into Y-chromosome genetic variability. The aim of this study was the detailed analysis of haplotype and haplogroup diversification in Croatian population. Methods: We carried out a statistical analysis of the data from previously performed genetic a analyses collected during routine forensic work by the Forensic Science Centre ‘‘Ivan Vučetić’’. A total of 1100 men from eastern, western, central, southern and northern Croatia were typed using AmpFISTR Yfiler PCR amplification kit. We estimated Y-chromosomal haplogroups from Croatian Y-STR haplotype data using Whit Atheys’ Haplogroup Predictor. Median-Joining Network (MJN) included all 17 Y-STR loci, and was constructed with Network 4.60 software. Software Splitstree 4.10 was used for creating the Neighbor-Joining (NJ) tree based on RST pair-wise distances between the Croatian and 15 neighboring populations. Results: Across all Croatian subpopulations I2a, R1a, E1b1b, and R1b haplogroups were the most frequent. Frequencies of I2a and E1b1b were significantly different between the Croatian subpopulations (P<0.05). Southern Croatian subpopulation was significantly different in R1b frequency from central and northern Croatia and in R1a frequency from northern Croatia. The NJ tree analysis detected that Croatian subpopulations were closely related to either southern (eastern, western and southern Croatia) or central (northern Croatia) European clusters, than they were related to each other. Central Croatian subpopulation lied on the boundary between these two clusters. Conclusion: Y-chromosomal biallelic markers should be analyzed further to explore Croatian genetic heritage in the future.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 053-0532265-2255
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Biologija,Temeljne medicinske znanosti
Upisao u CROSBI: gmrsic@public.hr (gmrsic@public.hr), 31. Kol. 2012. u 10:25 sati



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