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Pregled bibliografske jedinice broj: 591619

Časopis

Autori: Basarić, Nikola; Mlinarić-Majerski, Kata; Kralj, Marijeta
Naslov: Quinone methides: photochemical generation and its application in biomedicine
Izvornik: Current organic chemistry (1385-2728) 18 (2014), 1; 3-18
Vrsta rada: članak
Ključne riječi: DNA alkylating agents ; DNA cross-linking ; excited-state intramolecular proton transfer (ESIPT) ; photo-deammination ; photo-dehydration ; quinone methides
Sažetak:
Quinone methides (QMs) are important intermediates in chemistry and biochemistry of phenols that are characterized by wide biological activity. Some classes of anticancer antibiotics exhibit their effect due to methabolic formation of QMs that alkylate DNA. Photochemical reactions provide mild and easy approach to QMs. Photoreactions that give QMs include cleavage of oxa-heterocycles, dehydrohalogenation, dehydration, deammination, excited state intramolecular proton transfer (ESIPT) and tautomerizations of phenols. This critical review (137 references) features different photochemical reactions giving QMs that are applicable in biology and medicine.
Projekt / tema: 02.05/25
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti
URL Internet adrese: http://eurekaselect.com/119823/article
Broj citata:
Altmetric:
DOI: 10.2174/138527281801140121122330
URL cjelovitog teksta:
Google Scholar: Quinone methides: photochemical generation and its application in biomedicine
Upisao u CROSBI: eluksa@irb.hr (eluksa@irb.hr), 5. Ruj. 2012. u 10:48 sati



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