crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 592759

Časopis

Autori: Benci, Krešimir; Mandić, Leo; Suhina, Tomislav; Sedić, Mirela; Klobučar, Marko; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Wittine, Karlo; Mintas, Mladen
Naslov: Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity
Izvornik: Molecules (1420-3049) 17 (2012), 9; 11010-11025
Vrsta rada: članak
Ključne riječi: 1; 2; 4-triazole; 4; 5-dicyanoimidazole and purine coumarin derivatives; acyclic nucleoside analogues; antitumor activity evaluation
Sažetak:
We report here on the synthesis and in vitro anti-tumor effects of a series of novel 1, 2, 4-triazole (compounds 3–6), 4, 5-dicyanoimidazole (compound 7), and purine (compounds 8–13) coumarin derivatives and their acyclic nucleoside analogues 14–18. Structures of novel compounds 3–18 were deduced from their 1H- and 13C-NMR and corresponding mass spectra. Results of anti-proliferative assays performed on a panel of selected human tumor cell lines revealed that compound 6 had moderate cytostatic activity against the HeLa cell line (IC50 = 35 µM), whereas compound 10 showed moderate activity against the HeLa (IC50 = 33 µM), HepG2 (IC50 = 25 µM) and SW620 (IC50 = 35 µM) cell lines. These compounds showed no cytotoxic effects on normal (diploid) human fibroblasts.
Projekt / tema: 335-0000000-3532, 335-0982464-239, 125-0982464-2922
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija
URL Internet adrese: http://www.mdpi.com/1420-3049/17/9/11010
Broj citata:
Altmetric:
DOI: 10.3390/molecules170911010
URL cjelovitog teksta:
Časopis izlazi u samo elektroničkom izdanju: DA
Google Scholar: Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity
Upisao u CROSBI: mmintas@fkit.hr (mmintas@fkit.hr), 13. Ruj. 2012. u 10:20 sati



  Verzija za printanje   za tiskati


upomoc
foot_4