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Pregled bibliografske jedinice broj: 594935

Zbornik radova

Autori: Benci, Krešimir; Mandić, Leo; Suhina, Tomislav; Sedić, Mirela; Klobučar, Marko; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Wittine, Karlo; Mintas, Mladen
Naslov: Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moiety: Synthesis and Evaluation of Cytostatic Activity
Izvornik: XXIInd International Symposium on Medicinal Chemistry (ISMC 2012) : abstracts / Ortu´zar, Natalia (ur.). - Berlin : WILEY-VCH Verlag GmbH& Co. KGaA , 2012. 379-379.
ISSN: 1860-7179
Skup: International Symposium on Medicinal Chemistry (22 ; 2012)
Mjesto i datum: Berlin, Njemačka, 02-06.09.2012.
Ključne riječi: coumarin derivatives containing 1; 2; 4-triazole; 4; 5-dicyanoimidazole and purine moiety; cytostatic activity
Sažetak:
Here, we report the synthesis and in vitro antitumor effects of a series of novel 1, 2, 4-triazole (3–6), 4, 5-dicyanoimidazole (7), and purine (8–13) coumarin derivatives and their acyclic nucleoside analogues (14–18). The structures of novel compounds 3–18 were deduced from their 1H and 13C NMR data and corresponding mass spectra. Results of an antiproliferative assay performed on a panel of selected human tumor cell lines revealed that compound 6 has moderate cytostatic activity against the HeLa cell line (IC50=35 μm), whereas compound 10 shows moderate activity against HeLa (IC50=33 μm), HepG2 (IC50=25 μm) and SW620 (IC50=35 μm) cell lines. These compounds exhibited no cytotoxic effect on normal (diploid) human fibroblasts.
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Nema recenziju
Projekt / tema: 335-0000000-3532, 335-0982464-239, 125-0982464-2922
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Kemija
Upisao u CROSBI: mmintas@fkit.hr (mmintas@fkit.hr), 26. Ruj. 2012. u 12:14 sati



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