engleski

Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moiety: Synthesis and Evaluation of Cytostatic Activity

Here, we report the synthesis and in vitro antitumor effects of a series of novel 1, 2, 4-triazole (3–6), 4, 5-dicyanoimidazole (7), and purine (8–13) coumarin derivatives and their acyclic nucleoside analogues (14–18). The structures of novel compounds 3–18 were deduced from their 1H and 13C NMR data and corresponding mass spectra. Results of an antiproliferative assay performed on a panel of selected human tumor cell lines revealed that compound 6 has moderate cytostatic activity against the HeLa cell line (IC50=35 μm), whereas compound 10 shows moderate activity against HeLa (IC50=33 μm), HepG2 (IC50=25 μm) and SW620 (IC50=35 μm) cell lines. These compounds exhibited no cytotoxic effect on normal (diploid) human fibroblasts.

coumarin derivatives containing 1; 2; 4-triazole; 4; 5-dicyanoimidazole and purine moiety; cytostatic activity

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