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Pregled bibliografske jedinice broj: 596555

Časopis

Autori: Rudić, Milan; Nguyen, C.; Nguyen, Y.; Milković, Lidija; Žarković, Neven; Sterkers, O.; Ferrary, E.; Grayeli, A.B.
Naslov: Effect of Angiotensin II on Inflammation Pathways in Human Primary Bone Cell Cultures in Otosclerosis
Izvornik: Audiology and neuro-otology (1420-3030) 17 (2012), 3; 169-178
Vrsta rada: članak
Ključne riječi: bone dystrophy; Angiotensin II; hearing loss; inflammation; bone remodeling
Sažetak:
The aim of this study was to assess the expression and production of inflammation mediators in basal condition and after angiotensin II (AngII) in otosclerosis. Human stapedial cell cultures (6 otosclerosis and 6 controls) were incubated with AngII (10–7M, 24 h) or vehicle. Cytokines and their mRNA expression were assessed by antibody and cDNA arrays. In basal conditions, otosclerotic cultures produced higher amounts of interleukin (IL)-1β and interferon-inducible protein 10, and smaller amounts of tissue inhibitor of metalloproteinase 2. AngII promoted inflammation by increasing interferon γ and IL-10, and by decreasing macrophage inflammatory protein 1α and soluble tumor necrosis factor receptor II. Otosclerotic cultures produced higher proinflammatory cytokines in basal condition. AngII appeared to promote inflammation via these mediators in otosclerosis.
Projekt / tema: 098-0982464-2519, 108-0000000-0028
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.karger.com/Article/FullText/335098
Broj citata:
Altmetric:
DOI: 10.1159/000335098
URL cjelovitog teksta:
Google Scholar: Effect of Angiotensin II on Inflammation Pathways in Human Primary Bone Cell Cultures in Otosclerosis
Upisao u CROSBI: mstroser@mef.hr (mstroser@mef.hr), 4. Lis. 2012. u 08:26 sati



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