crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 602475

Časopis

Autori: Hranjec, Marijana; Sović, Irena; Ratkaj, Ivana; Pavlović, Gordana; Ilić, Nataša; Valjalo, Linda; Pavelić, Krešimir; Kraljević Pavelić, Sandra; Karminski-Zamola, Grace
Naslov: Antiproliferative potency of novel benzofuran-2-carboxamides on tumor cell lines : cell death mechanisms and determination of crystal structure
Izvornik: European journal of medicinal chemistry (0223-5234) 59 (2013); 111-119
Vrsta rada: članak
Ključne riječi: benzofuranes; carboxamides; antiproliferative activity; apoptosis; crystal structure determination
Sažetak:
In this manuscript the synthesis and biological activity of novel heterocyclic derivatives of benzofuran-2-carboxamides 3a-3j and 6a-6f is presented. Biological evaluation in vitro revealed that only few compounds exerted concentration-depended antiproliferative effects on tumour cell lines at micromolar concentrations. In particular, 2-imidazolynyl substituted compound 6f showed selectivity on SK-BR-3 cell line while 2-N-acetamidopyridyl substituted 3h and 2-imidazolynyl substituted amide 3i showed selective concentration-dependent antiproliferative effects on SW620 cell line. Compounds 3h and 6f induced apoptosis while compound 3i acted through a cell death mechanism other than apoptotis.
Projekt / tema: 335-0000000-3532, 335-0982464-2393, 098-1191344-2943, 125-0982464-1356
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti
URL Internet adrese: http://dx.doi.org/10.1016/j.ejmech.2012.11.009
http://www.sciencedirect.com/science/article/pii/S0223523412006782
http://ac.els-cdn.com/S0223523412006782/1-s2.0-S0223523412006782-main.pdf?_tid=21853cee-1ade-11e3-9578-00000aacb35e&acdnat=1378902889_b627b252bc94afbeeda1a7b57d459b6e
Broj citata:
Altmetric:
DOI: 10.1016/j.ejmech.2012.11.009
URL cjelovitog teksta: http://dx.doi.org/10.1016/j.ejmech.2012.11.009
Google Scholar: Antiproliferative potency of novel benzofuran-2-carboxamides on tumor cell lines : cell death mechanisms and determination of crystal structure
Upisao u CROSBI: mhranjec@fkit.hr (mhranjec@fkit.hr), 8. Stu. 2012. u 19:54 sati



  Verzija za printanje   za tiskati


upomoc
foot_4